Iodine and Thyroid Function Status, and Anti-thyroid Peroxidase Antibody among Pregnant Women in Eastern Nepal.
Iodine and Thyroid Function Status, and Anti-thyroid Peroxidase Antibody among Pregnant Women in Eastern Nepal.
复制标题
尼泊尔东部孕妇的碘和甲状腺功能状况以及抗甲状腺过氧化物酶抗体。
DOI：
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发表时间：
2017
影响因子：
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通讯作者：
N. Baral
中科院分区：
文献类型：
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作者：
L. Chaudhary;S. Khatiwada;B. Gelal;Sharad Gautam;M. Lamsal;H. Pokharel;N. Baral
背景
妊娠期碘缺乏、甲状腺功能障碍和甲状腺自身免疫的发展可能会影响母亲和发育中的胎儿。本研究旨在了解孕妇碘营养状况、甲状腺功能异常及甲状腺自身免疫状况。
方法
来自尼泊尔东部三个地区（Sunsari，Morang和Jhapa）的92名孕妇参加了这项研究，并收集了尿液和血液样本。尿碘浓度（UIC），游离甲状腺素（游离T4），促甲状腺激素（TSH），甲状腺球蛋白和抗甲状腺过氧化物酶（TPO）抗体水平进行了估计。
结果
孕妇UIC中位数为282.2（158.42 ~ 376）μg/L，游离T_4和TSH均值为1.14±0.41 ng/dL，甲状腺球蛋白中位数为4.57±2.56 IU/mL，抗TPO抗体中位数为6.5（4.0-11.0）ng/mL，抗TPO抗体中位数为1.52（0.97-2.23）IU/mL。碘摄入量不足（<150 μg/L）17例（18.5%），碘摄入量充足（150-249 μ g/L）22例（23.9%），碘摄入量超过需要量（250-499 μg/L）53例（57.6%）。亚临床甲状腺功能减退症和显性甲状腺功能减退症分别见于18例（19.5%）和1例（1.1%）女性。在3名（3.26%）妇女中观察到甲状腺球蛋白升高（>40 ng/mL）和抗TPO抗体阳性。
结论
近期孕妇碘摄入量充足，但少部分孕妇仍存在慢性碘缺乏症。轻度甲状腺功能障碍是常见的，甲状腺自身免疫存在于少数尼泊尔孕妇人群。
BACKGROUND
Iodine deficiency, thyroid dysfunction and development of thyroid autoimmunity during pregnancy may affect mother and the developing fetus. This study was carried out to find iodine status, thyroid dysfunction and thyroid autoimmunity among pregnant women.
METHODS
Ninety two pregnant women from three districts of eastern Nepal (Sunsari, Morang and Jhapa) were enrolled for the study, and urine and blood samples were collected. Urinary iodine concentration (UIC), free thyroxine (free T4), thyroid stimulating hormone (TSH), thyroglobulin and anti-thyroid peroxidase (TPO) antibody levels were estimated.
RESULTS
The median UIC, mean free T4 and TSH, median thyroglobulin and anti-TPO antibody in the pregnant women were 282.2 (158.42-376) μg/L, 1.14±0.41 ng/dL, 4.57±2.56 IU/mL, 6.5 (4.0-11.0) ng/mL, 1.52 (0.97-2.23) IU/mL respectively. In sufficient (<150 μg/L), adequate (150-249 μg/L) and above requirements (250-499 μg/L) iodine intake was observed in 17 (18.5%), 22 (23.9%) and 53 (57.6%) women respectively. Subclinical hypothyroidism and overt hypothyroidism were seen in 18 (19.5%) and 1(1.1%) women, respectively. Elevated thyroglobulin (>40 ng/mL) and positive anti-TPO antibody was observed in three (3.26%) women for both.
CONCLUSIONS
Iodine intake was sufficient among pregnant women recently, however, chronic iodine deficiency persisted in small fraction of pregnant women. Mild thyroid dysfunction was common, and thyroid autoimmunity was present in small portion of Nepalese pregnant women population.
影响因子：
6.6
作者：
Stagnaro-Green, Alex;Abalovich, Marcos;Wiersinga, Wilmar
通讯作者：
Wiersinga, Wilmar