ACETYLCHOLINE-RECEPTOR GENE-EXPRESSION IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA-GRAVIS
ACETYLCHOLINE-RECEPTOR GENE-EXPRESSION IN EXPERIMENTAL AUTOIMMUNE MYASTHENIA-GRAVIS
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DOI：
10.1016/0014-5793(90)80932-9
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发表时间：
1990-07-16
期刊：
影响因子：
3.5
通讯作者：
FUCHS, S
中科院分区：
文献类型：
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作者：
ASHER, O;NEUMANN, D;FUCHS, S
分析了乙酰胆碱受体（AChR）基因在兔、大鼠和小鼠实验性自身免疫性重症肌无力（EAMG）中的表达。AChR转录本的增加被证明与肌喘气病症状和膜AChR的严重丢失完全相关。在大鼠的EAMG中观察到α‐，β‐，λ‐和δ‐亚基特异性mrna的增加（分别为5.2‐，1.6‐，3.2‐和3.7‐倍），它们编码成人型AChR （α2βϵδ）。在肌无力或健康大鼠中未检测到γ -亚基转录物。看来，在EAMG中AChR基因表达的调控与在去神经支配中观察到的不同。
Acetylcholine receptor (AChR) gene expression was analyzed in experimental autoimmune myasthenia gravis (EAMG) in rabbits, rats and mice. An increase in AChR transcripts was demonstrated to be exclusively associated with myasthénie symptoms and with a severe loss in membrane AChR. An increase of α‐, β‐, ϵ‐, and δ‐subunit specific mRNAs (5.2‐, 1.6‐, 3.2‐ and 3.7‐fold, respectively), which code for the adult type of AChR (α2βϵδ) was observed in EAMG in rats. The γ‐subunit transcript was not detectable in myasthenie or healthy rats. It appears that the regulatory control of AChR gene expression in EAMG is different from that observed upon denervation.