THE BONE-MINERAL DENSITY IN ACQUIRED GROWTH-HORMONE DEFICIENCY CORRELATES WITH CIRCULATING LEVELS OF INSULIN-LIKE GROWTH FACTOR-I
THE BONE-MINERAL DENSITY IN ACQUIRED GROWTH-HORMONE DEFICIENCY CORRELATES WITH CIRCULATING LEVELS OF INSULIN-LIKE GROWTH FACTOR-I
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DOI：
10.1111/j.1365-2796.1992.tb00613.x
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发表时间：
1992-11-01
影响因子：
11.1
通讯作者：
LJUNGHALL, S
中科院分区：
文献类型：
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作者：
JOHANSSON, AG;BURMAN, P;LJUNGHALL, S
胰岛素样生长因子I （IGF-I）是体外成骨细胞的重要合成代谢因子。在患有骨质疏松症的年轻男性中观察到低血浆igf - 1水平。在本研究中，我们研究了获得性生长激素缺乏症成人的骨矿物质密度（BMD）和IGF-I和生长激素（GH）的循环水平。采用双能x线骨密度仪测定17名男性和12名女性（年龄27-54岁）的骨密度。脊柱骨密度与血浆IGF-I水平呈正相关（r = 0.43）。P = 0.019)，与夜间重复采样获得的GH值中位数（r = 0.43, P = 0.0019）和GHRH激发试验期间的GH值峰值（r = 0.49, P = 0.039）有关。总骨密度与血浆igf - 1和GH值中位数呈正相关，但与GHRH激发的GH峰值无关。在多元回归分析模型中，IGF-I、GHRH激发试验的GH峰值和GH缺乏持续时间解释了49%的脊柱骨密度变化。与健康对照组相比。生长激素缺乏症男性的总骨量（而非脊柱骨量）较低，但未观察到骨质疏松症的临床症状。骨密度与循环IGF-I及其他生长激素分泌指标呈正相关，提示IGF-I对骨量具有内分泌作用。
Insulin-like growth factor I (IGF-I) is an important anabolic factor for osteoblasts in vitro. Low plasma levels of IGF-I have been observed in young men with osteoporosis. In the present study, we have studied bone mineral density (BMD) and the circulating levels of IGF-I and growth hormone (GH) in adults with acquired GH deficiency. BMD was determined by dual-energy x-ray absorptiometry in 17 men and 12 women (age 27-54 years). Spinal BMD was positively correlated with the plasma levels of IGF-I (r = 0.43. P = 0.019), with the median of GH values obtained by repeated sampling at night (r = 0.43, P = 0.0019), and with the peak of GH values during GHRH provocation test (r = 0.49, P = 0.039). The total BMD was positively related to plasma IGF-I and median of GH values, but not to peak GH by GHRH provocation. In a multiple regression analysis model, IGF-I, peak GH by GHRH provocation test and duration of GH deficiency explained 49% of the variation in spinal BMD. As compared to healthy controls. total, but not spinal, bone mass was lower in men with GH deficiency, but no clinical symptoms of osteoporisis were observed. The positive relationships between BMD and circulating IGF-I and other indices of GH secretion suggest that IGF-I has an endocrine effect on bone mass.