Experimental validation of Haldane's hypothesis on the role of infection as an evolutionary force for Metazoans
Experimental validation of Haldane's hypothesis on the role of infection as an evolutionary force for Metazoans
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DOI：
10.1073/pnas.0704497104
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发表时间：
2007-08-21
影响因子：
11.1
通讯作者：
Martinez, Jose L.
中科院分区：
文献类型：
--
作者：
Navas, Alfonso;Cobas, Guillermo;Martinez, Jose L.
进化科学的一个共同缺点是，生物体的进化发生在地质时间，完全超出了实验室实验工作的时间尺度。由于这个原因，一些有关后生动物进化的假设是基于相关性，而不是为了测试这些假设的鲁棒性而获得的实验数据。在目前的工作中，我们实施了一个实验方法来分析感染的作用，作为一个驱动力的后生动物的进化（Halflion的假设）。为了实现这一目标，我们使用了简单的毒力模型，繁殖时间短，种群大，并且易于在实验室中进行测试。使用细菌病毒线虫秀丽隐杆线虫作为进化下的模式生物，其感染的环境条件致病菌铜绿假单胞菌作为选择力，我们已经证明，细菌感染选择进化的线虫谱系抗感染，其呼吸和消耗新的食物资源的能力的变化。使用实验的方法，我们表明，感染是一种选择性的力量，在进化的后生动物提出的Halfenan。
A common drawback in evolutionary science is the fact that the evolution of organisms occurs in geological timing, completely out of the time scale of laboratory experimental work. For this reason, some relevant hypotheses on evolution of Metazoans are based on correlations more than on experimental data obtained for testing the robustness of those hypotheses. In the current work, we implement an experimental methodology to analyze the role of infections as a driving force in the evolution of Metazoans (Haldane's hypothesis). To that goal, we have used simple models of virulence with short reproduction times, large populations, and that are easily testable in the laboratory. Using the bacteriovirus nematode Caenorhabditis elegans as a model organism under evolution and their infection by the environmental opportunistic bacterial pathogen Pseudomonas aeruginosa as the selective force, we have demonstrated that bacterial infection selects an evolved nematode lineage resistant to infection, with changes in its respiration and capability of consuming novel food resources. Using an experimental approach, we show that infection is a selective force in the evolution of Metazoans as proposed earlier by Haldane.