Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus.
Elevated interleukin-10 levels correlated with disease activity in systemic lupus erythematosus.
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发表时间：
1998-05
影响因子：
3.7
通讯作者：
Yong-Beom Park;S. Lee;Dong Soo Kim;Junga Lee;C. Lee;C. Song
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文献类型：
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作者：
Yong-Beom Park;S. Lee;Dong Soo Kim;Junga Lee;C. Lee;C. Song
目的检测系统性红斑狼疮(SLE)患者血清白介素10(IL-10)水平，探讨其与疾病活动性的关系。方法对41例系统性红斑狼疮患者和35例正常对照进行研究。所有SLE患者在出现活动期疾病时和开始治疗后4周收集配对血清样本。检测血清中IL-10水平，并与疾病活动性进行比较，使用SLE疾病活动性指数(SLEDAI)和实验室参数，如循环免疫复合物(CIC)、C3、C4、抗DNA抗体、免疫球蛋白G、免疫球蛋白M和免疫球蛋白A。结果SLE患者血清IL-10水平显著高于对照组(P<0.01)。SLE患者IL-10水平升高与SLEDAI呈正相关(r=0.46，p<；0.01)，而与其他实验室活动性指标无相关性。患者病程中血清IL-10水平的变化与SLEDAI评分的变化呈正相关(r=0.51，p<；0.01)。结论SLE患者血清IL-10水平升高，且IL-10水平升高与SLE病情活动密切相关。
OBJECTIVE To determine serum interleukin-10 (IL-10) levels in systemic lupus erythematosus (SLE) patients and to assess their relationship with disease activity. METHODS Forty-one SLE patients and 35 controls were studied. Paired serum samples were collected from all SLE patients at the time of their presentation with active disease and at 4 weeks after the institution of treatment. IL-10 levels were determined in the sera and were compared with disease activity, measured using the SLE Disease Activity Index (SLEDAI) and laboratory parameters such as the circulating immune complexes (CIC), C3, C4, anti-DNA antibody, IgG, IgM, and IgA. RESULTS The IL-10 levels in SLE patients were significantly higher than those of controls (mean +/- SE, 29.2 +/- 6.8 vs. 3.5 +/- 0.6 pg/ml, p < 0.01). Elevated IL-10 levels correlated well with the SLEDAI in SLE patients (r = 0.46, p < 0.01), but did not correlate with other laboratory activity indices. The changes in serum IL-10 levels also correlated with the changes in the SLEDAI score during the patients' disease course (r = 0.51, p < 0.01). CONCLUSION Serum levels of IL-10 are elevated in SLE patients and increased IL-10 correlates well with SLE disease activity.