Merging old and new perspectives on nicotinic acetylcholine receptors.
Merging old and new perspectives on nicotinic acetylcholine receptors.
复制标题
DOI：
10.1016/j.bcp.2014.01.029
复制
发表时间：
2014-05-01
影响因子：
5.8
通讯作者：
Papke RL
中科院分区：
文献类型：
--
作者：
Papke RL
这篇综述包括尼古丁在大脑中作用的分子介体的发现的历史和烟碱乙酰胆碱受体(NAChR)亚型的多样性。对它们的结构和作为信号转导媒介的功能提出了模型，特别考虑了两个主要亚型之间的差异：专用于快速电化学信号转导的异构体受体和参与电离性和代谢性信号转导的同构体α7受体。本文综述了nAChRs在治疗尼古丁依赖或疾病方面的药理和治疗靶向。
This review covers history underlying the discovery of the molecular mediators of nicotine's effects in the brain and the diversity of the nicotinic acetylcholine receptor (nAChR) subtypes. Models are presented for both their structure and their function as mediators of signal transduction, with special consideration of the differences between the two main subtypes: heteromeric receptors, which are specialized for rapid electrochemical signal transduction, and homomeric α7 receptors, which have come to be implicated in both ionotropic and metabotropic signaling. The review presents perspectives on the pharmacology and therapeutic targeting of nAChRs for the treatment of nicotine dependence or disease.