Absolute Power Spectral Density Changes in the Magnetoencephalographic Activity During the Transition from Childhood to Adulthood
Absolute Power Spectral Density Changes in the Magnetoencephalographic Activity During the Transition from Childhood to Adulthood
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DOI：
10.1007/s10548-016-0532-0
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发表时间：
2017-01-01
期刊：
影响因子：
2.7
通讯作者：
Gomez, Carlos
中科院分区：
文献类型：
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作者：
Gomez, Carlos M.;Rodriguez-Martinez, Elena I.;Gomez, Carlos
本研究的目的是确定模式的减少绝对功率谱密度（PSD）的脑磁图（MEG）信号在整个发展。具体来说，我们想探索人类头骨对电磁场的高渗透性是否允许我们质疑在人类脑电图中观察到的绝对PSD减少的模式是否是由于头骨的电阻特性随年龄增加而增加。此外，在成熟过程中的MEG信号的地形图进行了探索，提供了额外的见解有关的领域和大脑的节奏在人类大脑中的成熟后期。为了实现这些目标，从59名受试者的样本中记录了148个传感器的自发MEG活动，这些受试者分为三个年龄组：儿童/青少年（7-14岁），年轻人（17-20岁）和成人（21-26岁）。通过方差分析（ANOVA）进行统计检验，其中“年龄组”作为受试者间因素，“传感器组”作为受试者内因素。此外，计算绝对PSD与年龄的相关性，以评估年龄对MEG信号频谱内容的影响。结果表明，在额叶区的宽带PSD减少，这表明该地区的成熟较晚，但也有轻微的增加，高频PSD随着年龄的增长在后部地区。这些结果表明，在自发脑活动的神经源的强度随年龄的增长而下降，这可能与突触修剪。
The aim of this study was to define the pattern of reduction in absolute power spectral density (PSD) of magnetoencephalography (MEG) signals throughout development. Specifically, we wanted to explore whether the human skull's high permeability for electromagnetic fields would allow us to question whether the pattern of absolute PSD reduction observed in the human electroencephalogram is due to an increase in the skull's resistive properties with age. Furthermore, the topography of the MEG signals during maturation was explored, providing additional insights about the areas and brain rhythms related to late maturation in the human brain. To attain these goals, spontaneous MEG activity was recorded from 148 sensors in a sample of 59 subjects divided into three age groups: children/adolescents (7-14 years), young adults (17-20 years) and adults (21-26 years). Statistical testing was carried out by means of an analysis of variance (ANOVA), with "age group" as between-subject factor and "sensor group" as within-subject factor. Additionally, correlations of absolute PSD with age were computed to assess the influence of age on the spectral content of MEG signals. Results showed a broadband PSD decrease in frontal areas, which suggests the late maturation of this region, but also a mild increase in high frequency PSD with age in posterior areas. These findings suggest that the intensity of the neural sources during spontaneous brain activity decreases with age, which may be related to synaptic pruning.