Lipid peroxidation is associated with poor control of type-2 diabetes mellitus
Lipid peroxidation is associated with poor control of type-2 diabetes mellitus
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DOI：
10.1016/j.dsx.2016.01.028
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发表时间：
2016-04-01
影响因子：
10
通讯作者：
Almarzouki, Abdalla A.
中科院分区：
文献类型：
--
作者：
Fatani, Sameer Hassan;Babakr, Abdullatif Taha;Almarzouki, Abdalla A.
背景：高血糖通过活性氧的过量产生而增加氧化应激，从而导致自由基和细胞抗氧化防御系统之间的失衡。脂质过氧化水平与糖尿病并发症呈正相关。目的：本研究的目的是探讨控制和未控制的糖尿病患者的氧化应激状态。方法：本研究共纳入139名受试者，分为：i组：非糖尿病正常受试者的健康对照组；ii组：2型糖尿病控制组，2型糖尿病伴HbA1c的受试者占8%。测定空腹血糖、餐后2 h血糖、丙二醛（MDA）和糖化血红蛋白（HbA1c）。评估了糖尿病控制与脂质过氧化（丙二醛）之间的关系。结果：2型糖尿病未控制组的平均HbA1c较2型糖尿病控制组明显升高。与对照组相比，未控制的2型糖尿病组MDA表达的脂质过氧化水平显著升高，两组的该参数均较健康受试者显著升高。在研究对象中，MDA与HbA1c呈显著正相关。结论：糖尿病患者的核心问题是血糖控制不佳，导致蛋白质糖化、脂质过氧化、氧化应激等多种并发症的发生。建议定期评估糖尿病患者的脂质过氧化产物，因为它有助于早期识别和管理氧化应激。(C) 2016年印度糖尿病。Elsevier Ltd.出版。版权所有。
Background: Hyperglycemia increases oxidative stress through the overproduction of reactive oxygen species, which results in an imbalance between free radicals and the antioxidant defense system of the cells. A positive correlation was reported between lipid peroxide levels and diabetic complication.Objectives: The aim of the present study was to investigate the state of oxidative stress in controlled and uncontrolled diabetic patients.Methods: One hundred thirty nine participants were included in this study, grouped as: Group-I: Healthy Control group of non-diabetic normal subjects, Group-II: Controlled type-2 DM group of subjects with type-2 DM and HbA1c 8%. Fasting blood glucose, 2 h postprandial glucose, MDA and HbA1c were quantified. The association between diabetic control and lipid peroxidation (malondialdehyde) was evaluated.Results: The mean HbA1c increased significantly in uncontrolled type-2 DM subjects compared to controlled type-2 DM group. Lipid peroxidation as expressed in MDA was significantly increased in uncontrolled type-2 DM group compared to controlled type-2 DM, both groups show significant elevation in this parameter compared to healthy subjects. There is a significant positive correlation between MDA and HbA1c in the studied subjects.Conclusion: The core problem during diabetes is poor glycemic control, which leads to protein glycation, lipid peroxidation, oxidative stress and finally varieties of complications. Periodic evaluation of lipid peroxidation products in diabetes mellitus is recommended as it could contribute to the early identification and management of oxidative stress. (C) 2016 Diabetes India. Published by Elsevier Ltd. All rights reserved.