Clustering of genes into regulons using integrated modeling-COGRIM.
Clustering of genes into regulons using integrated modeling-COGRIM.
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DOI：
10.1186/gb-2007-8-1-r4
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发表时间：
2007
期刊：
影响因子：
12.3
通讯作者：
Stoeckert CJ Jr
中科院分区：
文献类型：
--
作者：
Chen G;Jensen ST;Stoeckert CJ Jr
COGRIM, an implementation that integrates gene expression, ChIP binding and transcription factor motif data, is described and applied to both unicellular and mammalian organisms. We present a Bayesian hierarchical model and Gibbs Sampling implementation that integrates gene expression, ChIP binding, and transcription factor motif data in a principled and robust fashion. COGRIM was applied to both unicellular and mammalian organisms under different scenarios of available data. In these applications, we demonstrate the ability to predict gene-transcription factor interactions with reduced numbers of false-positive findings and to make predictions beyond what is obtained when single types of data are considered.
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影响因子：
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作者：
Boulesteix, Anne-Laure;Strimmer, Korbinian
通讯作者：
Strimmer, Korbinian
DOI：
10.1073/pnas.2136632100
发表时间：
2003-12-23
影响因子：
11.1
作者：
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通讯作者：
Roychowdhury, VP
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Mewes, HW;Frishman, D;Weil, B
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Johnston, LH