Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction
Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction
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DOI：
10.3892/etm.2015.2443
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发表时间：
2015-07-01
影响因子：
2.7
通讯作者：
Cao, Zhigang
中科院分区：
文献类型：
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作者：
Jiang, Xi;Luo, Yong;Cao, Zhigang
本研究的目的是调查 microRNA (miR)-93、miR-320 和 miR-16 的表达，并评估它们对患有勃起功能障碍 (ED) 的糖尿病患者的诊断价值。共有120名受试者被分为三组，即糖尿病合并ED组（ED组）、糖尿病非ED组（NED组）和健康志愿者组（对照组）。每组有 40 人。采集血清样本，对三类miRNA进行逆转录定量聚合酶链反应检测，并通过受试者工作特征曲线分析ED的敏感性。糖尿病患者ED发生率与血清总睾酮水平呈负相关（r=0.302，P
The aim of the present study was to investigate the expression of microRNA (miR)-93, miR-320 and miR-16 and to assess their diagnostic value in diabetic patients with erectile dysfunction (ED). A total of 120 individuals were divided into three groups, which included the diabetics with ED group (ED group), the diabetics without ED group (NED group) and the healthy volunteers group (control group). Each group included 40 individuals. Serum samples were collected and reverse transcription quantitative polymerase chain reaction detection of the three types of miRNA was performed and the sensitivity of ED was analyzed by receiver operating characteristic curves. A negative correlation was identified between the incidence of ED in patients with diabetes and serum total testosterone levels (r=0.302, P