Human IGG1 and IGG4:: The main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins
Human IGG1 and IGG4:: The main antibodies against Triatoma infestans (Hemiptera: Reduviidae) salivary gland proteins
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DOI：
10.4269/ajtmh.2001.65.219
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发表时间：
2001-09-01
影响因子：
3.3
通讯作者：
Teixeira, ARL
中科院分区：
文献类型：
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作者：
Nascimento, RJ;Santana, JM;Teixeira, ARL
致病锥虫唾液腺蛋白（TSGP）可诱导人体局部和全身超敏反应。与生活在无锥虫地区的对照组相比，恰加斯病患者和生活在锥虫出没地区的个体血清中存在更高水平的针对TSGP的IgG抗体。TSGP特异性IgG（1）在查加斯病患者和生活在锥蝽出没的农村地区的个体的血清中被发现，而独特的特异性IgG（4）存在于生活在锥蝽出没地区的查加斯病患者的血清中，对TSGP具有反应性。在对普遍存在的致倦库蚊唾液蛋白（CSGP）反应的个体血清中未检测到独特的特异性。总之，抗TSGP的IgG（1）反应性是生活在锥蝽侵扰研究区域的个体中存在的主要抗体。此外，IgG（4）被发现在昆虫传播的查加斯病患者的血清中生活在研究领域。
The Triatoma infestans salivary gland proteins (TSGP) can induce local and systemic hypersensitivity reactions in humans. IgG antibodies against TSGP were present in higher levels in sera of Chagas disease patients, and in individuals living in triatomine-infested areas than in controls living in triatomine-free areas. TSGP-specific IgG(1) was found in sera of Chagas patients, and of individuals living in triatomine-infested rural areas, and uniquely specific IgG(4) was present in sera of Chagas patients living in triatomine-infested areas, reactive against TSGP. Unique specificities were not detected in sera of individuals reacting against the ubiquitous mosquito Culex quinquifasciatus saliva proteins (CSGP). In conclusion, IgG(1) reactive against TSGP is the main antibody present in individuals living in the triatomine-infested study areas. Also, IgG(4) is found in the sera of insect-transmitted Chagas disease patients living in study areas.