Matricellular proteins as regulators of cancer metastasis to bone.
Matricellular proteins as regulators of cancer metastasis to bone.
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DOI：
10.1016/j.matbio.2016.01.006
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Yang Y
中科院分区：
文献类型：
--
作者：
Trotter TN;Yang Y
转移是癌症患者死亡的主要原因，骨髓是许多癌症的常见转移部位。因此，了解转移过程的机制对未来的预防和治疗是必要的。目前已知肿瘤微环境在原发肿瘤和转移部位的转移级联反应中起作用，包括细胞和非细胞成分。细胞外基质（ECM）为细胞提供结构支持和信号提示。与ECM相关的一组特殊分子，被称为基质细胞蛋白，调节肿瘤生物学的多个方面，包括生长、迁移、侵袭、血管生成和转移。这些蛋白质通过调节骨形成和骨吸收对骨的正常功能也很重要。最近的研究描述了其中一些蛋白质与各种肿瘤骨转移之间的联系。本综述的目的是总结目前已知的基质细胞蛋白对骨转移的影响。特别注意肿瘤细胞和非恶性细胞在骨中的作用。
Metastasis is the major cause of the death in cancer patients, and a frequent site of metastasis for many cancers is the bone marrow. Therefore, understanding the mechanisms underlying the metastatic process is necessary for future prevention and treatment. The tumor microenvironment is now known to play a role in the metastatic cascade, both at the primary tumor and in metastatic sites, and includes both cellular and non-cellular components. The extracellular matrix (ECM) provides structural support and signaling cues to cells. One particular group of molecules associated with the ECM, known as matricellular proteins, modulate multiple aspects of tumor biology, including growth, migration, invasion, angiogenesis and metastasis. These proteins are also important for normal function in the bone by regulating bone formation and bone resorption. Recent studies have described a link between some of these proteins and metastasis of various tumors to the bone. The aim of this review is to summarize what is currently known about matricellular protein influence on bone metastasis. Particular attention to the contribution of both tumor cells and non-malignant cells in the bone has been given.