A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome
A Mycobacterium tuberculosis IS6110 preferential locus (ipl) for insertion into the genome
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DOI：
10.1128/jcm.35.2.479-481.1997
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发表时间：
1997-02-01
影响因子：
9.4
通讯作者：
Forbes, KJ
中科院分区：
文献类型：
--
作者：
Fang, ZG;Forbes, KJ
一个267个核苷酸的结核分枝杆菌基因组序列（ipl，IS6110优先基因座），它可以携带插入序列IS6110在六个替代位置已被确定在约四分之三的测试分离株。在检测的含ipl：：IS6110（+）的分离株中，在该基因座处仅观察到一个IS6110拷贝，并且所有插入具有相同的方向。在这项工作中，这一发现的影响，IS6110指纹分型方法进行了讨论。
A 267-nucleotide Mycobacterium tuberculosis genomic sequence (ipl, the IS6110 preferential locus) which can harbor the insertion sequence IS6110 at six alternative locations has been identified in some three-quarters of the isolates tested. Only one IS6110 copy was observed at this locus in the ipl::IS6110(+)-containing isolates tested, and all insertions had the same orientation. The implications of this finding for IS6110 fingerprint typing methods is discussed in this work.