The differentiation-associated linker histone, H1.0, during the in vitro aging and senescence of human diploid fibroblasts
The differentiation-associated linker histone, H1.0, during the in vitro aging and senescence of human diploid fibroblasts
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DOI：
10.1196/annals.1395.039
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Sourlingas, Thomae G.
中科院分区：
文献类型：
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作者：
Sekeri-Pataryas, Kalliope E.;Sourlingas, Thomae G.
老化/衰老和分化之间有许多相似之处。一个关键的相似之处是，在这两个生物过程中，染色质重塑事件发生。现在知道，在这两个过程中，有一个重组的eu和异染色质结构域和异染色质的增加，称为异染色质化。二十多年来的先前工作已经表明，替换HI接头组蛋白亚型H1.0在许多细胞/组织系统中的终末分化期间积累。然而，在衰老细胞系统中与这种分化相关的HI亚型的工作最近才完成。在这篇文章中，我们概述了累积的结果，从我们的调查HIM蛋白和mRNA水平在体外老化细胞系统的人二倍体成纤维细胞（HDFs），并讨论了潜在的理由，为什么这个特定的亚型被发现在这两个过程中积累。
There are numerous similarities between aging/senescence and differentiation. One key similarity is that in both biological processes chromatin remodeling events occur. It is now known that during both processes there is a reorganization of eu- and heterochromatic domains and an increase in heterochromatin, known as heterochromatinization. Previous work of more than two decades has shown that the replacement HI linker histone subtype, H1.0, accumulates during terminal differentiation in numerous cell/tissue systems. However, work with this differentiation-associated HI subtype in aging cell systems has only recently been accomplished. In this article, we outline the cumulative results from our investigations of HIM protein and mRNA levels in the in vitro aging cell system of human diploid fibroblasts (HDFs) and discuss the potential rationale of why this particular subtype was found to accumulate during both these processes.