Recent Patents on Topical Application of Honey in Wound and Burn Management
Recent Patents on Topical Application of Honey in Wound and Burn Management
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DOI：
10.2174/187221311794474847
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发表时间：
2011-01-01
影响因子：
4.2
通讯作者：
Manivannan, Lavaniya
中科院分区：
文献类型：
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作者：
Benhanifia, Mokhtar B.;Boukraa, Laid;Manivannan, Lavaniya
蜂蜜局部应用于烧伤和伤口已被发现是有效的控制感染，并产生一个干净的造粒床。提示蜂蜜的伤口愈合作用可能部分与周围组织细胞主要是单核细胞和巨噬细胞释放炎性细胞因子有关。据报道，蜂蜜通过加速伤口收缩来加速伤口愈合。显微镜评价表明，蜂蜜处理的伤口有明显的皮肤修复加速作用。在体内评估下的宏观和微观观察表明，蜂蜜的局部应用可能对烧伤和伤口愈合的各个阶段产生有利影响，从而加速愈合过程。蜂蜜的调节作用与糖以外的成分有关。然而，蜂蜜影响单核细胞释放抗炎剂和生长因子的机制尚不清楚。蜂蜜是否影响其他细胞类型，特别是内皮细胞和成纤维细胞，参与伤口愈合也需要澄清。本文简要回顾了蜂蜜在伤口和烧伤治疗中的愈合效果的最新专利。
Topical application of honey to burn and wounds has been found to be effective in controlling infection and producing a clean granulating bed. It is suggested that the wound healing effect of honey may in part be related to the release of inflammatory cytokines from surrounding tissue cells, mainly monocytes and macrophages. It has been reported that honey hastens wound healing by accelerating wound contractions. Microscopic evaluation demonstrated that there was a significant acceleration of dermal repair in wound treated with honey. Macroscopic and microscopic observations under in vivo assessment suggested that the topical application of honey might have favourable influences on the various phases of burn and wound healing hence accelerating the healing process. The regulatory effects of honey are related to components other than the sugars. However, the mechanisms by which honey affects the release of anti inflammatory agents and growth factors from monocytic cells are as yet unclear. Whether honey affects other cell types, particularly endothelial cells and fibroblasts, involved in wound healing also needs to be clarified. The present article is a short review of recent patents on the healing effect of honey in wound and burn management.