Checkpoint control of mitotic exit--do budding yeast mind the GAP?
Checkpoint control of mitotic exit--do budding yeast mind the GAP?
复制标题
有丝分裂退出的检查点控制——芽殖酵母介意GAP吗？
DOI：
10.1083/jcb.200512153
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
Nelson,ScottA
中科院分区：
文献类型：
--
作者：
Cooper,JohnA;Nelson,ScottA
细胞周期检查点可以延迟芽殖酵母的有丝分裂退出。主控制器是小的GTAPTEM 1，其输入来自提议的鸟嘌呤核苷酸交换因子（GEF）Lte 1和GTP酶激活蛋白（GAP）Bub 2/Bfa 1。在这个问题上，Fraschini等人（第335页）表明，Bub 2/Bfa 1的GAP活性似乎与细胞中Tem 1的失活有关。他们的研究结果对Tem 1活性的GTP/GDP转换模型提出了质疑，就像过去的其他结果一样。本文还重点关注的两个纺锤体作为潜在的网站Tem 1的监管。
Cell cycle checkpoints can delay mitotic exit in budding yeast. The master controller is the small GTPase Tem1, with inputs from a proposed guanine nucleotide exchange factor (GEF), Lte1, and a GTPase-activating protein (GAP), Bub2/Bfa1. In this issue, Fraschini et al. (p. 335) show that GAP activity of Bub2/Bfa1 appears to be dispensable for inactivation of Tem1 in cells. Their results call into question the GTP/GDP switch model for Tem1 activity, as have other results in the past. The paper also focuses attention on the two spindle pole bodies as potential sites for regulation of Tem1.