Surfactant-induced Chronic Pruritus: Role of L-Histidine Decarboxylase Expression and Histamine Production in Epidermis
Surfactant-induced Chronic Pruritus: Role of L-Histidine Decarboxylase Expression and Histamine Production in Epidermis
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DOI：
10.2340/00015555-1834
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发表时间：
2014-01-01
影响因子：
3.6
通讯作者：
Kuraishi, Yasushi
中科院分区：
文献类型：
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作者：
Inami, Yoshihiro;Sasaki, Atsushi;Kuraishi, Yasushi
含有阴离子表面活性剂的洗发水和清洁剂，包括十二烷基硫酸钠(十二烷基硫酸钠)，经常会引起人类的瘙痒。每天应用1-10%的十二烷基硫酸钠4天，可引起小鼠的后爪抓挠(一种与瘙痒有关的行为)，并呈浓度依赖性；10%的十二烷基硫酸钠还可引起小鼠皮炎、皮肤干燥、屏障破坏和皮肤表面pH值升高。阿片受体拮抗剂纳洛酮和H-1组胺受体拮抗剂特非那丁可抑制十二烷基硫酸钠诱导的抓挠。肥大细胞缺乏并不能抑制十二烷基硫酸钠引起的划痕，尽管它几乎完全耗尽了真皮中的组胺。用十二烷基硫酸钠处理增加了表皮的组胺含量，但不增加真皮的组胺含量。十二烷基硫酸钠处理增加了L-组氨酸脱羧酶在表皮中的基因表达和翻译后加工。本研究结果提示，反复使用十二烷基硫酸钠可通过增加表皮组胺的产生而引起皮肤瘙痒，这是L组氨酸脱羧酶基因表达增加和翻译后加工的结果。
Shampoo and cleansers containing anionic surfactants including sodium dodecyl sulphate (SDS) often cause pruritus in humans. Daily application of 1-10% SDS for 4 days induced hind-paw scratching (an itch-related behaviour) in a concentration-dependent manner, and 10% SDS also caused dermatitis, skin dryness, barrier disruption, and an increase in skin surface pH in mice. SDS-induced scratching was inhibited by the opioid receptor antagonist naloxone and the H-1 histamine receptor antagonist terfenadine. Mast-cell deficiency did not inhibit SDS-induced scratching, although it almost completely depleted histamine in the dermis. Treatment with SDS increased the histamine content of the epidermis, but not that of the dermis. SDS treatment increased the gene expression and post-translation processing of L-histidine decarboxylase in the epidermis. The present results suggest that repeated application of SDS induces itch through increased production of epidermal histamine, which results from an increase in the gene expression and post-translation processing of L-histidine decarboxylase.