Insights into the Genetic History of French Cattle from Dense SNP Data on 47 Worldwide Breeds
Insights into the Genetic History of French Cattle from Dense SNP Data on 47 Worldwide Breeds
复制标题
DOI：
10.1371/journal.pone.0013038
复制
发表时间：
2010-09-30
期刊：
影响因子：
3.7
通讯作者：
Moazami-Goudarzi, Katayoun
中科院分区：
文献类型：
--
作者：
Gautier, Mathieu;Laloe, Denis;Moazami-Goudarzi, Katayoun
背景资料：现代牛起源于大约8,000年前发生的几次驯化事件中灭绝的野生欧洲野牛。新驯化的种群随后沿着繁殖者迁移路线在世界范围内传播。由此产生的与自然和人工选择相关的复杂历史起源导致了许多不同牛品种的分化，这些牛品种在短时间内表现出广泛的表型多样性。方法学/主要发现：本研究基于1，来自世界不同地区的47个群体中的121个个体（特别关注法国牛）对44，706个常染色体SNP进行基因分型。分析的数据集包括代表14个法国牛品种的296个个体的新基因型，这些新基因型与先前发表的三项研究中的基因型相结合。在描述了不同群体中的SNP多态性之后，我们在个体和群体水平上对遗传结构进行了详细的分析。我们进一步寻找23个欧洲人群之间的遗传多样性的空间格局，其中大部分是法国的起源，根据最近开发的空间主成分分析framework.Conclusions/Significance：总体而言，这样的高通量基因分型数据证实了明确的分区牛的遗传多样性到不同的品种。此外，三个主要群体的人口-非洲牛磺酸，欧洲牛磺酸和斑马-之间的分化模式可能会提供一些额外的支持三个不同的驯化中心。最后，在欧洲牛品种的调查，遗传多样性的空间格局被发现在良好的协议，向法国的两个主要的迁移路线，最初假设的基础上考古证据。
Background: Modern cattle originate from populations of the wild extinct aurochs through a few domestication events which occurred about 8,000 years ago. Newly domesticated populations subsequently spread worldwide following breeder migration routes. The resulting complex historical origins associated with both natural and artificial selection have led to the differentiation of numerous different cattle breeds displaying a broad phenotypic variety over a short period of time.Methodology/Principal Findings: This study gives a detailed assessment of cattle genetic diversity based on 1,121 individuals sampled in 47 populations from different parts of the world (with a special focus on French cattle) genotyped for 44,706 autosomal SNPs. The analyzed data set consisted of new genotypes for 296 individuals representing 14 French cattle breeds which were combined to those available from three previously published studies. After characterizing SNP polymorphism in the different populations, we performed a detailed analysis of genetic structure at both the individual and population levels. We further searched for spatial patterns of genetic diversity among 23 European populations, most of them being of French origin, under the recently developed spatial Principal Component analysis framework.Conclusions/Significance: Overall, such high throughput genotyping data confirmed a clear partitioning of the cattle genetic diversity into distinct breeds. In addition, patterns of differentiation among the three main groups of populations-the African taurine, the European taurine and zebus-may provide some additional support for three distinct domestication centres. Finally, among the European cattle breeds investigated, spatial patterns of genetic diversity were found in good agreement with the two main migration routes towards France, initially postulated based on archeological evidence.