A microfabricated porous collagen-based scaffold as prototype for skin substitutes
A microfabricated porous collagen-based scaffold as prototype for skin substitutes
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DOI：
10.1007/s10544-007-9155-2
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发表时间：
2008-06-01
影响因子：
2.8
通讯作者：
Sia, Samuel K.
中科院分区：
文献类型：
--
作者：
Chin, Curtis D.;Khanna, Krishn;Sia, Samuel K.
An important element of artificial skin is a tissue scaffold that allows for fast host regeneration. We present a microfabrication strategy, based on gelling collagen-based components inside a microfluidic device, that produces well-controlled pore sizes inside the scaffold. This strategy can produce finely patterned tissue scaffolds of clinically relevant dimensions suitable for surgical handling. Compared to porous collagen-based sponges produced by lyophilization, microfabricated tissue scaffolds preserve the fibrous structure and ligand density of natural occurring collagen. A fibroblast migration assay revealed fast cellular migration through the pores, which is desired for rapid tissue ingrowth. Finally, we also demonstrate a strategy to use this microfabrication technique to build anatomically accurate, multi-component skin substitutes in a cost-effective manner.
