Ketone body metabolism in diabetic and non-diabetic heart failure
Ketone body metabolism in diabetic and non-diabetic heart failure
复制标题
糖尿病和非糖尿病心力衰竭的酮体代谢
DOI：
10.1007/s10741-019-09857-3
复制
发表时间：
2019-10-15
影响因子：
4.6
通讯作者：
Wang, Yaping
中科院分区：
文献类型：
--
作者：
Qian, Ningjing;Wang, Yaping
心力衰竭是最常见的心血管疾病之一，在世界范围内造成巨大的疾病和经济负担。代谢平衡受损已被证实是HF的一个重要方面，底物利用的改变在HF的发展中起着至关重要的作用。糖尿病与心力衰竭密切相关，糖尿病患者心力衰竭的发病率和死亡率较高。此外，与非糖尿病患者相比，HF患者和糖尿病动物表现出不同的代谢模式和底物利用特征。近年来，酮体被证明是HF的一种替代能源，它可以改善心肌能量供应，从而适应HF。研究测量了不同组患者和动物模型中的酮体氧化和酮体代谢产物。本文综述了糖尿病性心力衰竭时酮体代谢的变化，并比较了糖尿病性心力衰竭与非糖尿病性心力衰竭的不同结果及其可能的机制。
Heart failure (HF) is one of the most common cardiovascular diseases, causing large disease and economic burden worldwide. Impaired metabolic balance has been confirmed as a significant aspect of HF, and alteration of substrate utilization plays a vital role in the development of HF. Diabetes mellitus is strictly related with HF, and patients with diabetes show a higher mortality and morbidity of HF. Furthermore, HF patients and animals with diabetes behave different characteristics of metabolic pattern and substrate utilization comparing to those without diabetes. Recently, ketone body has been demonstrated as an alternative energy source in HF, which may improve myocardial energy supply and thus be adaptive for HF. Studies measured ketone body oxidation and production of ketone body metabolism in different groups of patients and animal models. This review focuses on the alteration of ketone body metabolism during HF and compares different results between diabetic and non-diabetic HF and the potential mechanism.