Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid β-Peptide Aggregation and Neurotoxicity
Effects of Cyclen and Cyclam on Zinc(II)- and Copper(II)-Induced Amyloid β-Peptide Aggregation and Neurotoxicity
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DOI：
10.1021/ic900025x
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发表时间：
2009-07-06
影响因子：
4.6
通讯作者：
Guo, Zijian
中科院分区：
文献类型：
--
作者：
Chen, Tingting;Wang, Xiaoyong;Guo, Zijian
淀粉样β-肽（A β）聚集与阿尔茨海默病高度相关，其由Zn 2+和Cu 2+促进。大环多胺螯合剂cyclen和cyclam能有效地保护A β免受Cu ~（2+）或Zn ~（2+）诱导的沉淀;这些螯合剂也能抑制Cu-A β介导的H_2O_2的产生。
Amyloid beta-peptide (A beta) aggregation is highly associated with Alzheimer's disease, which is facilitated by Zn2+ and Cu2+. Macrocyclic polyamine chelators cyclen and cyclam, can effectively protect A beta against precipitation induced by Cu2+ or Zn2+; the production of H2O2 mediated by Cu-A beta can also be inhibited by these chelators.