Cancer in the HIV-Infected Host: Epidemiology and Pathogenesis in the Antiretroviral Era
Cancer in the HIV-Infected Host: Epidemiology and Pathogenesis in the Antiretroviral Era
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DOI：
10.1007/s11904-015-0283-7
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发表时间：
2015-12-01
影响因子：
4.6
通讯作者：
Palefsky, Joel M.
中科院分区：
文献类型：
--
作者：
Brickman, Cristina;Palefsky, Joel M.
癌症和艾滋病毒有着千丝万缕的联系。尽管抗逆转录病毒疗法的出现导致了与免疫抑制有关的恶性肿瘤(艾滋病定义恶性肿瘤，或ADMS)发病率的显著下降，但伴随着这种下降，其他恶性肿瘤(非艾滋病定义恶性肿瘤，NADM)的发病率也随之上升。以人口为基础的癌症登记提供了有关资源丰富国家内艾滋病毒携带者(PLWH)癌症流行病学的关键信息。与普通人群相比，PLWH患NADMS的风险更高，尤其是肺癌和肛门癌。促成因素包括烟草使用、与人乳头瘤病毒等致癌病毒的混合感染，以及艾滋病毒本身的潜在直接影响。来自资源贫乏国家的数据有限，并突显了在大多数人的生命周期中居住的国家进行更多研究的必要性。早期发现和/或预防癌症的策略在PLWH中是必要的。
Cancer and HIV are inextricably linked. Although the advent of antiretroviral therapy has led to a marked decline in the incidence of malignancies classically linked to immunosuppression (AIDS-defining malignancies, or ADMs), this decrease has been accompanied by a concomitant rise in the incidence of other malignancies (non-AIDS-defining malignancies, or NADMs). Population-based cancer registries provide key information about cancer epidemiology in people living with HIV (PLWH) within resource-rich countries. The risk for NADMs is elevated in PLWH compared with the general population, particularly for lung and anal cancers. Contributory factors include tobacco use, coinfection with oncogenic viruses such as human papillomavirus, and potentially direct effects of HIV itself. Data from resource-poor countries are limited and highlight the need for more studies in countries where the majority of PLWH reside. Strategies for early cancer detection and/or prevention are necessary in PLWH.