Design of a novel polymeric heart valve
Design of a novel polymeric heart valve
复制标题
DOI：
10.3109/03091900903261241
复制
发表时间：
2010-01-01
影响因子：
--
通讯作者：
Zervides, C.
中科院分区：
文献类型：
--
作者：
Burriesci, G.;Marincola, F. Cavallo;Zervides, C.
通过结合机械和生物假体瓣膜的优点，聚合物心脏瓣膜可以为当前假体提供最佳替代品。尽管最近出现了许多适合该应用的材料，但仍然需要对阀门设计进行重大改进。本文提出了一种新型聚合物心脏瓣膜设计，并描述了基于有限元的优化程序。该设计策略旨在减少运行周期中吸收的能量，从而实现高流体动力性能并降低应力水平。通过将循环期间数值预测的阀门动力学和应力水平与现有且合格的聚合物阀门设计进行比较，评估了设计策略的有效性。通过脉冲复制器的体外测试，实验证实了所提出的设计改进的流体动力学性能。
Polymeric heart valves could offer an optimum alternative to current prostheses, by joining the advantages of mechanical and bioprosthetic valves. Though a number of materials suitable for this application have recently become available, significant improvements in the valve design are still needed. In this paper, a novel polymeric heart valve design is proposed and its optimization procedure, based on the use of finite elements, is described. The design strategy was aimed at reducing the energy absorbed during the operating cycle, resulting in high hydrodynamic performances and reduced stress levels. The efficacy of the design strategy was assessed by comparing the valve dynamics and stress levels predicted numerically during the cycle with those of an existing and well qualified polymeric valve design. The improved hydrodynamic performance of the proposed design was confirmed experimentally, by in vitro testing in a pulse duplicator.