Role of Wnt signaling in bone remodeling and repair.
Role of Wnt signaling in bone remodeling and repair.
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DOI：
10.1007/s11420-007-9072-1
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发表时间：
2008-02-01
期刊：
影响因子：
--
通讯作者：
Lane, Joseph M
中科院分区：
文献类型：
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作者：
Issack, Paul S;Helfet, David L;Lane, Joseph M
Wnt基因编码一类高度保守的信号传导因子，这些因子是包括肌肉骨骼和神经结构在内的几种组织发育所必需的。越来越多的证据表明，Wnt信号传导对于骨量增加、骨重建和骨折修复至关重要。Wnt蛋白与细胞表面受体结合并激活控制核基因表达的信号通路;这种Wnt调节的基因表达控制细胞生长和分化。Wnt途径的许多组分最近已被表征，并且在小鼠和人类中该途径中的特定功能丧失或功能获得突变分别导致骨形成不足或过量的病症。药理学靶向Wnt信号传导途径的组分将允许操纵骨形成和重塑，并且将具有若干矫形应用，包括增强骨不连和骨质疏松症中的骨形成以及限制成骨肿瘤和异位骨化中的病理性骨形成。
The Wnt genes encode a highly conserved class of signaling factors required for the development of several types of tissues including musculoskeletal and neural structures. There is increasing evidence that Wnt signaling is critical for bone mass accrual, bone remodeling, and fracture repair. Wnt proteins bind to cell-surface receptors and activate signaling pathways which control nuclear gene expression; this Wnt-regulated gene expression controls cell growth and differentiation. Many of the components of the Wnt pathway have recently been characterized, and specific loss-of-function or gain-of-function mutations in this pathway in mice and in humans have resulted in disorders of deficient or excess bone formation, respectively. Pharmacologically targeting components of the Wnt signaling pathway will allow for the manipulation of bone formation and remodeling and will have several orthopedic applications including enhancing bone formation in nonunion and osteoporosis and restricting pathologic bone formation in osteogenic tumors and heterotopic ossification.