Meta-analysis of sensorimotor gating in patients with autism spectrum disorders
Meta-analysis of sensorimotor gating in patients with autism spectrum disorders
复制标题
DOI：
10.1016/j.psychres.2017.09.016
复制
发表时间：
2018-04-01
影响因子：
11.3
通讯作者：
Liu, Chia-Yih
中科院分区：
文献类型：
--
作者：
Cheng, Chia-Hsiung;Chang, Pei-Ying S.;Liu, Chia-Yih
惊吓反应的前脉冲抑制（PPI）是精神病患者（包括自闭症谱系障碍（ASD）患者）感觉运动门控能力的公认神经生理学标志。PPI已被用作中枢抑制功能的指标，并可能与该疾病的临床特征相关。然而，与健康对照组相比，ASD患者是否表现出PPI缺陷仍无定论。本荟萃分析旨在探讨PPI在ASD患者中的汇总效应量。我们检索了1990年至2017年1月的主要电子数据库。获得了7项研究，包括21项个体研究，其中包括135名健康对照和99名ASD患者。估计效应量，计算为Hedges g和95%置信区间。总体而言，我们发现ASD患者与健康对照组相比，PPI受损（p = 0.008）。具体而言，与健康儿童相比，ASD儿童/青少年中观察到显着的PPI缺陷（p = 0.019）。然而，在成人中未观察到PPI反应的差异。总之，我们的研究结果与以前的研究相一致，表明ASD儿童/青少年，而不是成年人，与健康对照组相比，表现出减少的感觉运动门控功能。我们还建议PPI的参数特别重要，应谨慎解释结果。
Prepulse inhibition (PPI) of startle response is a well-established neurophysiological marker of sensorimotor gating ability in psychiatric patients including those with autism spectrum disorders (ASD). PPI has been utilized as an indicator of the central inhibitory function and is potentially linked to the clinical features of this disease. However, it remains inconclusive whether ASD patients exhibit PPI deficits compared with healthy controls. The present meta-analysis aimed to explore the pooled effect sizes of PPI in ASD patients. We searched major electronic databases from 1990 to January 2017. Seven studies, consisting of 21 individual investigations with 135 healthy controls and 99 ASD patients, were obtained. The effect size, calculated as Hedges's g and 95% confidence interval, were estimated. Overall, we found ASD patients exhibited an impaired PPI compared with healthy controls (p = 0.008). Specifically, significant PPI deficits were observed among ASD children/adolescents, compared with their healthy counterparts (p = 0.019). However, differences in PPI responses were not observed among adults. Conclusively, our results reconciled the previous studies and showed that ASD children/adolescents, but not adults, exhibit reduced sensorimotor gating function compared to healthy controls. We also suggest that the parameters of PPI are particularly important and the results should be interpreted with cautions.