Impact of age- and gender-specific cut-off values for the fecal immunochemical test for hemoglobin in colorectal cancer screening
Impact of age- and gender-specific cut-off values for the fecal immunochemical test for hemoglobin in colorectal cancer screening
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DOI：
10.1016/j.dld.2016.02.001
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发表时间：
2016-05-01
影响因子：
4.5
通讯作者：
Bessa, Xavier
中科院分区：
文献类型：
--
作者：
Alvarez-Urturi, Cristina;Andreu, Montserrat;Bessa, Xavier
背景：没有关于年龄和性别对血红蛋白粪便免疫化学检测 (FIT) 不同阳性阈值诊断率的影响的信息。目的：在基于人群的结直肠癌 (CRC) 筛查计划中评估该测试在不同阳性截止值下的性能。方法：在不同的 FIT 截止值（20、25、25）下，回顾性评估 CRC 检出率 (DR) 和资源分析。在 ColonPrev 研究 (Quintero. NEJM 2013) 的 10,611 名参与者的筛查人群中，根据年龄和性别，相对于参考值 (15 tig Hb/g)，分别为 30、35 和 40 tig Hb/g。 结果：在参考截止值，诊断出 36 例 CRC 和 252 例晚期腺瘤 (AA)。将女性的截止值提高到 60 岁，所有截止值的增加都会影响 CRC DR，特别是当截止值从 35 tig Hb/g 增加到 40 tig Hb/g 时（CRC 漏检率 25%）。结论：为了提高 FIT 在 CRC 筛查项目中的表现，可以根据年龄和性别对 FIT 截止值进行个体化。 (C) 2016 Editrice Gastroenterologica Italiana S.r.l.由爱思唯尔有限公司出版。保留所有权利。
Background: There is no information on the impact of age and gender on the diagnostic yield of different positivity thresholds for the fecal immunochemical test for hemoglobin (FIT).Objectives: To evaluate the performance of this test at distinct positivity cut-offs in a population -based colorectal cancer (CRC) screening program.Methods: CRC detection rate (DR), and analysis of resources were evaluated retrospectively, at different cut-offs of FIT (20, 25, 30, 35 and 40 tig Hb/g) respect to a reference value (15 tig Hb/g), according to age and gender, in a screening population of 10,611 participants of the ColonPrev study (Quintero. NEJM 2013).Results: At the reference cut-off value, 36 CRC and 252 advanced adenomas (AA) were diagnosed. Increasing the cut-off in women 60 years, all increases in the cut-off affected the CRC DR, especially when the cut-off was increased from 35 to 40 tig Hb/g (CRC miss rate 25%).Conclusions: To improve the performance of FIT in CRC screening programs, FIT cut-offs could be individualized by age and gender. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.