Cross talking of network motifs in gene regulation that generates temporal pulses and spatial stripes
Cross talking of network motifs in gene regulation that generates temporal pulses and spatial stripes
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DOI：
10.1111/j.1365-2443.2005.00897.x
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发表时间：
2005-11-01
期刊：
影响因子：
2.1
通讯作者：
Shibata, T
中科院分区：
文献类型：
--
作者：
Ishihara, S;Fujimoto, K;Shibata, T
基因调控网络包含几个称为网络基序的子结构，它们经常存在于整个网络中。在大肠杆菌、酿酒酵母和黑腹果蝇中发现的这样的基序之一是前馈环，其中效应物通过直接调节相互作用和由另一基因产物介导的间接相互作用来调节其靶标。在这里，我们从理论上分析了包含前馈回路的网络的行为。响应于效应物的水平，这样的网络可以产生多个上升和下降的时间表达谱和空间条纹，这通常在发育过程中观察到。产生这些反应的机制揭示了从实验结果推断调控途径的方法。我们对基因调控网络的数据库研究表明，大多数前馈回路实际上是串扰。我们讨论了前馈回路和它们的串扰如何在形态发生中发挥重要作用。
Gene regulatory networks contain several substructures called network motifs, which frequently exist throughout the networks. One of such motifs found in Escherichia coli, Saccharomyces cerevisiae, and Drosophila melanogaster is the feed-forward loop, in which an effector regulates its target by a direct regulatory interaction and an indirect interaction mediated by another gene product. Here, we theoretically analyze the behavior of networks that contain feed-forward loops cross talking to each other. In response to levels of the effecter, such networks can generate multiple rise-and-fall temporal expression profiles and spatial stripes, which are typically observed in developmental processes. The mechanism to generate these responses reveals the way of inferring the regulatory pathways from experimental results. Our database study of gene regulatory networks indicates that most feed-forward loops actually cross talk. We discuss how the feed-forward loops and their cross talks can play important roles in morphogenesis.