Capillary gas chromatography/mass spectrometry with a microwave discharge interface for determination of radioactive carbon-containing compounds
Capillary gas chromatography/mass spectrometry with a microwave discharge interface for determination of radioactive carbon-containing compounds
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具有微波放电接口的毛细管气相色谱/质谱法用于测定放射性含碳化合物
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
F. Abramson
中科院分区：
文献类型：
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作者：
S. Markey;F. Abramson
复杂有机基质中的微量化合物在检测和结构解析方面都对有机质谱师提出了分析挑战。利用低压微波诱导等离子体界面将毛细管GC流出物中的所有含碳化合物转化为CO和CO/sub 2/，其可以在常规质谱仪中测量而不损失色谱分辨率并且检测限为300-500 dpm。给出了室温下正己烷异构体进样分离时，用该界面获得的色谱分离度。使用在215/sup 0/C下进行等温色谱分析的（1-/sup 14/C）棕榈酸甲酯样品评估了该技术作为放射性监测剂的潜力。反应GC/MS界面不限于作为反应气体的氧，也不限于作为可分析元素的碳。观察到碳与氮完全反应形成HCN和（CN）/sub 2/或与H/sub 2/完全反应形成CH/sub 4/。破坏性界面的使用具有通用性的优点;不需要关于所研究的元素或核素的位置或化学性质的信息。三位数。
Minor compounds in complex organic matrices represent an analytical challenge to organic mass spectroscopists, both in their detection and in structure elucidation. A low-pressure microwave-induced plasma interface was exploited to convert all carbon-containing compounds in a capillary GC effluent to CO and CO/sub 2/ which can be measured in a conventional mass spectrometer without loss of chromatographic resolution and with a detection limit of 300-500 dpm. The chromatographic resolution obtained with the interface when a sample of isomeric hexanes was injected and separated at room temperature was given. The potential of the technique as a radioactivity monitor was assessed with a sample of methy (1-/sup 14/C) palmitate which was chromatographed isothermally at 215/sup 0/C. The reaction GC/MS interface is not limited to oxygen as the reactant gas nor to carbon as the analyzable element. Complete reaction of carbon either with nitrogen to form HCN and (CN)/sub 2/ or with H/sub 2/ to form CH/sub 4/ was seen. The use of a destructive interface has the advantage of generality; no information is needed about the position or the chemistry of the element or nuclide under investigation. 3 figures.