Tripping a switch: PDZRhoGEF rgRGS-bound Galpha13.
Tripping a switch: PDZRhoGEF rgRGS-bound Galpha13.
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触发开关：PDZRhoGEF rgRGS 结合的 Galpha13。
DOI：
10.1016/j.str.2008.09.003
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Buck,Matthias
中科院分区：
文献类型：
--
作者：
Hamaneh,MehdiBagheri;Buck,Matthias
Ras superfamily guanine nucleotide-binding proteins, such as G-proteins and small GTPases, are a paradigm for two-state molecular switches in cell signaling. Recent experimental and theoretical studies question this simple model. Now Chen et al. (2008) provide evidence that the rgRGS domain of PDZRhoGEF has evolved to "trip" the nucleotide-dependent switch of the subunit of the heterotrimeric G-protein, Gα13, so that it can also bind to its GDP state.
