URINARY FREE CORTISOL EXCRETION IN DEPRESSION
URINARY FREE CORTISOL EXCRETION IN DEPRESSION
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DOI：
10.1017/s0033291700007480
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发表时间：
1976-01-01
影响因子：
6.9
通讯作者：
SUGERMAN, AA
中科院分区：
文献类型：
--
作者：
CARROLL, BJ;CURTIS, GC;SUGERMAN, AA
在 60 名抑郁症住院患者和 35 名患有其他疾病的精神病住院患者中测定了尿游离皮质醇 (UFC) 排泄量。抑郁症患者的每日 UFC 值较高，而其他患者的排泄量正常。超过 40% 的抑郁症患者的 UFC 排泄量与库欣病的范围相同，而其他患者中只有 6% 的皮质醇排泄量如此之高。年龄和性别差异并未解释结果。在抑郁症患者中，患有抑郁性神经症的患者的排泄量低于单相或双相抑郁症患者。治疗后，抑郁症患者的 UFC 排泄量变得更加正常。详细讨论了 UFC 的估计及其临床实用性。 UFC 测定是肾上腺皮质激活的简单且信息丰富的指标，建议将其应用于心理内分泌研究。
Urinary free Cortisol (UFC) excretion was determined in 60 depressed inpatients and in 35 psychiatric inpatients with other disorders. The depressed patients had high daily UFC values, while the other patients excreted normal amounts. Over 40% of the depressed patients had UFC excretions in the range seen in Cushing's disease, while only 6% of the other patients excreted such high amounts of Cortisol. Age and sex differences did not account for the results. Among the depressed patients those with depressive neuroses excreted less than unipolar or bipolar depressives. Following treatment, more normal UFC excretion was found in depressed patients. The estimation of UFC and its clinical utility are discussed in detail. UFC determination is a simple and informative indicator of adrenal cortical activation and its application to psychoendocrine studies is recommended.