IMGT unique numbering for the variable (V), constant (C), and groove (G) domains of IG, TR, MH, IgSF, and MhSF.
IMGT unique numbering for the variable (V), constant (C), and groove (G) domains of IG, TR, MH, IgSF, and MhSF.
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DOI：
10.1101/pdb.ip85
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发表时间：
2011-06-01
影响因子：
--
通讯作者：
Lefranc, Marie-Paule
中科院分区：
文献类型：
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作者：
Lefranc, Marie-Paule
“IMGT 唯一编号”（或“IMGT_unique_numbering”）概念是 IMGT-ONTOLOGY 的主要计数概念（由 NUMEROTATION 公理生成），IMGT-ONTOLOGY 是免疫遗传学和免疫信息学的全球参考，由国际 ImMunoGeneTics 信息系统 IMGT 构建。这里描述的“IMGT 唯一编号”概念允许对蛋白质超家族特征的结构域类型进行编号，无论物种、分子类型或链类型如何。已分别针对免疫球蛋白超家族 (IgSF) 的可变 (V) 结构域和恒定 (C) 结构域以及主要组织相容性 (MH) 超家族 (MhSF) 的凹槽 (G) 结构域定义了三个叶概念（叶概念是对应于最细粒度水平的概念）。 IMGT 独特的编号概念是免疫遗传学和系统生物学领域的重大突破，首次允许弥合任何 V、C 或 G 结构域的氨基酸（和核苷酸）序列及其二维 (2D) 和三维 (3D) 结构之间的间隙。 IMGT 独特的编号概念对于 IMGT Collier de Perles 的创建以及 IMGT 数据库、工具和网络资源中的突变、氨基酸变化、多态性和接触分析的描述标准化至关重要。
The “IMGT unique numbering”(or “IMGT_unique_numbering”) concept is a major concept of numerotation (generated from the NUMEROTATION axiom) of IMGT-ONTOLOGY, the global reference in immunogenetics and immunoinformatics, built by IMGT, the international ImMunoGeneTics information system. The “IMGT unique numbering” concept, described here, allows one to number domain types that are characteristic of protein superfamilies, whatever the species, the molecule type or the chain type. Three leafconcepts (a leafconcept is a concept that corresponds to the finest level of granularity) have been defined, respectively, for the variable (V) domain and constant (C) domain of the immunoglobulin superfamily (IgSF) and for the groove (G) domain of the major histocompatibility (MH) superfamily (MhSF). The IMGT unique numbering concept has been a great breakthrough in immunogenetics and systems biology in allowing, for the first time, the bridging of the gap between amino acid (and nucleotide) sequences of any V, C, or G domain and their two-dimensional (2D) and three-dimensional (3D) structures. The IMGT unique numbering concept has been fundamental in the creation of the IMGT Collier de Perles and in the standardization of the description of mutations, amino acid changes, polymorphisms, and contact analysis in the IMGT databases, tools, and web resources.