Carbon nanotubes for the delivery of therapeutic molecules.
Carbon nanotubes for the delivery of therapeutic molecules.
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DOI：
10.1517/17425247.1.1.57
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发表时间：
2004-11-01
影响因子：
6.6
通讯作者：
Bianco, Alberto
中科院分区：
文献类型：
--
作者：
Bianco, Alberto
功能化碳纳米管（f-CNTs）是纳米生物技术和纳米医学领域的新工具。这是因为它们可以通过用生物聚合物包封或通过将增溶基团共价连接到外壁和尖端来容易地操纵和修饰。将f-CNTs结合到生物系统中的可能性为探索其在生物学和药物化学中的潜在应用开辟了道路。在不同的应用领域（即，生物传感器、复合材料、分子电子学），CNT的一种用途是作为用于递送治疗分子的新载体系统。在这篇评论中讨论的研究集中在最近的进展，在开发的CNT技术的药物，抗原和基因的交付。
Functionalised carbon nanotubes (f-CNTs) are emerging as new tools in the field of nanobiotechnology and nanomedicine. This is because they can be easily manipulated and modified by encapsulation with biopolymers or by covalent linking of solubilising groups to the external walls and tips. The possibility of incorporating f-CNTs into biological systems has opened the way to the exploration of their potential applications in biology and medicinal chemistry. Within the different fields of applications (i.e., biosensors, composite materials, molecular electronics), one use of CNTs is as new carrier systems for the delivery of therapeutic molecules. Research discussed in this review is focused on recent advances in the development of CNT technology for the delivery of drugs, antigens and genes.