Individual differences in cognitive decline in schizophrenia
Individual differences in cognitive decline in schizophrenia
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DOI：
10.1176/ajp.155.8.1117
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发表时间：
1998-08-01
影响因子：
17.7
通讯作者：
van Kammen, DP
中科院分区：
文献类型：
--
作者：
Goldstein, G;Allen, DN;van Kammen, DP
作者的目标是确定认知障碍的精神分裂症患者是否表现出与年龄相关的认知下降，类似于没有实质性认知障碍的精神分裂症患者。方法：在一组77名精神分裂症患者中，计算年龄与平均损伤等级（认知能力的概括指数）之间的相关系数。这些患者分为两组：一组认知功能接近正常（N=51），另一组认知功能严重受损（N=26）。老年痴呆患者组（N=21）和非精神分裂症患者对照组（N=299）作为参照组。结果如下：年龄和平均损害评级之间有显着的相关性，在所有组中，除了认知功能障碍的精神分裂症患者，其中零阶相关。结论：有严重认知功能障碍的精神分裂症患者的年龄与认知功能之间不存在轻度认知功能障碍或正常认知功能障碍的精神分裂症患者的显著相关性，这表明认知功能障碍的精神分裂症患者的认知功能障碍发作较早。
The authors' goal was to determine whether cognitively impaired patients with schizophrenia exhibit age-related cognitive declines similar to those of patients with schizophrenia who do not have substantial cognitive impairment. Method: Correlation coefficients were computed between age and the Average impairment Rating, a summary index of cognitive ability, in a group of 77 patients with schizophrenia. These patients were clustered into two groups: one with near-normal cognitive function (N=51) and one with severely impaired cognitive function (N=26). A group of patients with senile dementia (N=21) and another comparison group of nonschizophrenic patients (N=299) were used as reference groups. Results: There were significant correlations between age and the Average Impairment Rating in all groups except the cognitively impaired patients with schizophrenia, in which a zero-order correlation was obtained. Conclusions: Patients with schizophrenia who have substantial cognitive impairment do not have the significant correlation between age and cognitive function found in patients with schizophrenia who have mildly impaired or normal cognitive abilities, suggesting earlier onset of cognitive deficit in the cognitively impaired patients with schizophrenia.