In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism.
In vivo 1H-magnetic resonance spectroscopy study of the attentional networks in autism.
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DOI：
10.1016/j.brainres.2010.12.057
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发表时间：
2011-03-22
期刊：
影响因子：
2.9
通讯作者：
Fan J
中科院分区：
文献类型：
--
作者：
Bernardi S;Anagnostou E;Shen J;Kolevzon A;Buxbaum JD;Hollander E;Hof PR;Fan J
注意力障碍是自闭症谱系障碍(ASD)患者最一致的发现之一。然而，这些发现对自闭症的病理生理学的意义尚不清楚。在这项研究中，我们用质子磁共振波谱成像(1H-MRS)研究了与ASD患者注意的警报、定向和执行控制网络相关的脑区的细胞神经化学。用3T1H-MRS测定了14例无药物治疗的ASD患者和14例年龄、智商相匹配的健康对照(HC)脑内N-乙酰天冬氨酸(NAA)、肌酸+磷酸肌酸、胆碱类化合物、肌醇(INS)和谷氨酸+谷氨酰胺(GLX)的含量。与HC组相比，ASD组右侧ACC的GLX浓度显著降低，左侧TPJ的INS浓度显著降低。这项研究提供了与辅助执行控制和注意警报的网络相关的神经传递异常的证据，这些功能以前被认为与ASD的发病有关。
Attentional dysfunction is one of the most consistent findings in individuals with autism spectrum disorders (ASD). However, the significance of such findings for the pathophysiology of autism is unclear. In this study, we investigated cellular neurochemistry with proton magnetic resonance spectroscopy imaging (1H-MRS) in brain regions associated with networks subserving alerting, orienting, and executive control of attention in patients with ASD. Concentrations of cerebral N-acetyl-aspartate (NAA), creatinine + phosphocreatinine, choline-containing compounds, myo-inositol (Ins) and glutamate + glutamine (Glx) were determined by 3 T 1H-MRS examinations in 14 high-functioning medication-free adults with a diagnosis of ASD and 14 age- and IQ-matched healthy controls (HC) in the anterior cingulate cortex (ACC), thalamus, temporoparietal junction (TPJ), and areas near or along the intraparietal sulcus (IPS). Compared to HC group, the ASD group showed significantly lower Glx concentrations in right ACC and reduced Ins in left TPJ. This study provides evidence of abnormalities in neurotransmission related to networks subserving executive control and alerting of attention, functions which have been previously implicated in ASD pathogenesis.
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