Secretory carcinoma around Stensen's duct misdiagnosed as salivary duct cyst.
Secretory carcinoma around Stensen's duct misdiagnosed as salivary duct cyst.
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Stensen 导管周围分泌癌误诊为唾液管囊肿。
DOI：
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发表时间：
2020
影响因子：
1.4
通讯作者：
T. Yoda
中科院分区：
文献类型：
--
作者：
Eri Shibata;Kei;Kou Kayamori;M. Maruiwa;Y. Michi;Yukiko Sato;K. Takeuchi;Tohru Ikeda;H. Harada;T. Yoda
2010年发现了唾液腺分泌性癌（SC），其特征在于特异性ETV 6基因排列。SC最常见的原发部位是腮腺;然而，Stensen导管周围的SC是罕见的。在这里，我们描述了一个罕见的情况下，SC周围的Stensen导管，最初被误诊为唾液腺管囊肿。一位59岁的妇女提出了一个肿块在该地区的左腮腺乳头。磁共振成像（MRI）显示一个边界清楚的病变和增强，边缘和内壁样部分，出现在晚期阶段。根据初步的临床和影像学表现，诊断为腮腺涎腺导管囊肿。然而，基于免疫组织化学结果，病变被组织病理学诊断为SC。肿瘤细胞显示AE 1/AE 3、波形蛋白和乳房珠蛋白的弥漫性阳性染色以及S-100蛋白、SOX-10和DOG-1的局灶性阳性染色。荧光原位杂交显示肿瘤中ETV 6基因重排。在Stensen导管周围的囊性病变的情况下，临床医生应该记住，它们可能是小涎腺癌，如SC。
Secretory carcinoma (SC) of the salivary gland was identified in 2010, and it is characterized by a specific ETV6 gene arrangement. The most common primary site for SC is the parotid gland; however, SC around the Stensen's duct is rare. Here we describe a rare case of a SC around the Stensen's duct that was initially misdiagnosed as a salivary duct cyst. A 59-year-old woman presented with a mass in the region of the left parotid papilla. Magnetic resonance imaging (MRI) revealed a well-circumscribed lesion and enhancement with a rim and an inner wall-like part that appeared in the late phase. Based on the initial clinical and imaging findings, a salivary duct cyst of the parotid gland was diagnosed. However, the lesion was histopathologically diagnosed as a SC based on immunohistochemical findings. The tumor cells showed diffuse positive staining for AE1/AE3, vimentin, and mammaglobin and focal positive staining for S-100 protein, SOX-10, and DOG-1. Fluorescence in-situ hybridization revealed ETV6 gene rearrangement in the tumor. In cases of cystic lesions around the Stensen's duct, clinicians should bear in mind that the possibility that they could be minor salivary gland cancers, such as SC.
影响因子：
28.2
作者：
Vaishnavi A;Le AT;Doebele RC
通讯作者：
Doebele RC
影响因子：
4.8
作者：
Ziv, Inbal;Fuchs, Yaron;Ron, Dina
通讯作者：
Ron, Dina