Alcohol consumption and plasma atrial natriuretic peptide (from the HyperGEN study)
Alcohol consumption and plasma atrial natriuretic peptide (from the HyperGEN study)
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DOI：
10.1016/j.amjcard.2006.03.041
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发表时间：
2006-09-01
影响因子：
2.8
通讯作者：
Ellison, Robert Curtis
中科院分区：
文献类型：
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作者：
Djousse, Luc;Hunt, Steven C.;Ellison, Robert Curtis
虽然适度饮酒与较低的心血管疾病风险相关，但潜在的生理机制尚未完全了解。有关饮酒与心房利钠肽（ANP）的数据一直不一致。我们评估了来自高血压遗传流行病学网络（HyperGEN）研究的1345名参与者的饮酒是否与血浆ANP相关。我们使用随机效应模型来估计对数变换ANP的调整均值。平均年龄35.8±8.6岁，91%血压正常，46%为男性，非洲裔美国人和白人分别占40%和60%。在一个调整了年龄、体重指数、场地中心、教育程度、性别、种族和血清白蛋白的模型中，饮酒与男性（趋势p < 0.0001）和女性（p = 0.0014）以及非洲裔美国人（p = 0.006）和白人（p < 0.0001）的ANP呈正相关。在终生戒酒者、曾经饮酒者和现在饮酒者（1 ~ 6、7 ~ 12、13 ~ 24和100 ~ 24 g/d）中，对数变换ANP的调整平均值分别为3.68、3.67、3.77、3.76、3.86和3.91 pg/ml。控制其他因素，包括左心房大小、射血分数、左心室质量、舒张末期容积、收缩压、吸烟、血脂和血清肌酐没有改变结果。限制血压正常的受试者也得到了类似的结果。酒精摄入量与收缩压和舒张压呈正相关（趋势p < 0.0001）。总之，我们的数据显示，无论种族，男性和女性，饮酒与ANP之间都存在正线性关联。(c) 2006爱思唯尔公司
Although moderate alcohol consumption has been associated with a lower risk of cardiovascular disease, underlying physiologic mechanisms are not fully understood. Data relating alcohol intake to atrial natriuretic peptide (ANP) have been inconsistent. We evaluated whether alcohol consumption was associated with plasma ANP in 1,345 participants from the Hypertension Genetic Epidemiology Network (HyperGEN) study. We used random effect models to estimate the adjusted means of logarithmic transformed ANP. The mean age was 35.8 +/- 8.6 years, 91% were normotensive, 46% were men, and 40% and 60% were African-Americans and whites, respectively. In a model adjusting for age, body mass index, field center, education, gender, race, and serum albumin, alcohol consumption was positively associated with ANP in men (p < 0.0001 for trend) and women (p = 0.0014) and in African-Americans (p = 0.006) and whites (p < 0.0001). The adjusted mean of log-transformed ANP was 3.68, 3.67, 3.77, 3.76, 3.86, and 3.91 pg/ml in lifetime abstainers, former drinkers, and current drinkers of 1 to 6, 7 to 12, 13 to 24, and > 24 g/d, respectively. Controlling for additional factors, including left atrial size, ejection fraction, left ventricular mass, end-diastolic volume, systolic blood pressure, smoking, lipids, and serum creatinine did not change the results. Restriction to normotensive subjects yielded similar results. Alcohol intake was associated positively with systolic and diastolic blood pressure (p < 0.0001 each for trend). In conclusion, our data have shown a positive and linear association between alcohol consumption and ANP in men and women, irrespective of race. (c) 2006 Elsevier Inc.