Depressive symptoms and health-related quality of life in early pregnancy
Depressive symptoms and health-related quality of life in early pregnancy
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DOI：
10.1097/01.aog.0000204190.96352.05
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发表时间：
2006-04-01
影响因子：
7.2
通讯作者：
Powe, Neil R.
中科院分区：
文献类型：
--
作者：
Nicholson, Wanda K.;Setse, Rosanna;Powe, Neil R.
目的：抑郁症状可能与妊娠后期较低的健康相关生活质量有关。很少有研究量化抑郁症状对怀孕早期或种族和经济多样化群体的影响。我们的目标是评估妊娠早期不同女性群体中抑郁症状与健康相关生活质量的独立关联。方法：我们对 175 名在社区和大学环境中接受产前护理的孕妇进行了一项横断面研究。我们将抑郁症状的存在（定义为流行病学研究中心抑郁量表得分为 16 分或以上）与来自 8 个医疗结果研究简表领域的健康相关生活质量得分相关联：身体功能、角色身体、身体疼痛、活力、一般健康、社会功能、角色情绪和心理健康。使用分位数回归来衡量抑郁症状与 8 个领域中每一个领域的独立关联。 结果：研究样本为 49% 非洲裔美国人、38% 白人和 11% 亚洲人。平均（+/- 标准差）胎龄为 14 +/- 6 周。抑郁症状的患病率为15%。有抑郁症状的女性在除身体功能外的所有领域的健康相关生活质量得分均显着较低。调整社会人口统计学、临床和社会支持因素后，抑郁症状与健康相关生活质量评分相关，角色身体评分降低 30 分，身体疼痛评分降低 19 分，一般健康评分降低 10 分，角色情感评分降低 56 分。 结论：妊娠早期出现抑郁症状的女性健康相关生活质量较差。早期识别和治疗孕妇的抑郁症状可能会提高她们的幸福感。
OBJECTIVE: Depressive symptoms can be associated with lower health-related quality of life in late pregnancy. Few studies have quantified the effect of depressive symptoms in early pregnancy or among a racially and economically diverse group. Our goal was to estimate the independent association of depressive symptoms with health-related quality of life among a diverse group of women in early pregnancy.METHODS: We conducted a cross-sectional study of 175 pregnant women receiving prenatal care in a community and university-based setting. We related the presence of depressive symptoms, defined as a Center for Epidemiologic Studies Depression Scale score of 16 or more to health-related quality of life scores from the 8 Medical Outcomes Study Short Form domains: Physical Functioning, Role-Physical, Bodily Pain, Vitality, General Health, Social Functioning, Role-Emotional, and Mental Health. Quantile regression was used to measure the independent association of depressive symptoms with each of the 8 domains.RESULTS: The study sample was 49% African American, 38% white, and 11% Asian. Mean (+/- standard deviation) gestational age was 14 +/- 6 weeks. The prevalence of depressive symptoms was 15%. Women with depressive symptoms had significantly lower health-related quality of life scores in all domains except Physical Functioning. After adjustment for sociodemographic, clinical, and social support factors, depressive symptoms were associated with health-related quality of life scores that were 30 points lower in Role-Physical, 19 points lower in Bodily Pain, 10 points lower in General Health, and 56 points lower in Role-Emotional.CONCLUSION: Women in early pregnancy with depressive symptoms have poor health-related quality of life. Early identification and management of depressive symptoms in pregnant women may improve their sense of well-being.