A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.
A metastatic orthotopic-transplant nude-mouse model of human patient breast cancer.
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DOI：
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发表时间：
1993-07
影响因子：
2
通讯作者：
X. Fu;P. Le;R. Hoffman
中科院分区：
文献类型：
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作者：
X. Fu;P. Le;R. Hoffman
我们在这里报告了人类乳腺癌患者裸鼠原位移植模型的发展。将组织学完整的患者乳腺肿瘤组织作为完整组织移植到裸鼠乳腺脂肪垫中，肿瘤组织广泛生长并转移到肺部。这是第一个人类乳腺癌原位移植转移模型。讨论了该模型在临床和基础科学方面的潜在应用。
We report here the development of an orthotopic-transplant model of human patient breast cancer in nude mice. Histologically-intact patient breast tumor tissue was transplanted as intact tissue to the mammary fat pad of nude mice where the tumor tissue grew extensively and metastasized to the lung. This is the first orthotopic-transplant metastatic model of human breast cancer. The potential clinical and basic-science uses of the model are discussed.