Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity.
Effects of Spermidine on Mouse Gut Morphology, Metabolites, and Microbial Diversity.
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亚精胺对小鼠肠道形态、代谢物和微生物多样性的影响
作者：
亚精胺是一类具有生物活性的有机小分子，在维持肠道内环境稳定方面起着重要作用。本研究的具体目的是探讨亚精胺对小鼠肠道形态、代谢产物和微生物多样性的影响。结果表明，0.3mmol/L亚精胺能显著促进回肠绒毛的生长（p < 0.05），3.0mmol/L亚精胺能显著增加小鼠体重，促进空肠绒毛的生长（p < 0.05）。16 S rDNA序列分析结果表明，3.0 mmol/L亚精胺通过增加肠道乳酸菌的丰度，降低肠道有害菌（Turicibacter和Alistipes）的丰度，影响肠道植物群的平衡。此外，亚精胺影响微生物代谢物如琥珀酸和泛酰巯基乙胺的水平。综上所述，亚精胺影响肠道形态，调节肠道植物群和代谢产物，本研究为亚精胺对肠道的影响提供了新的认识。
Spermidine is a class of biologically active organic small molecules that play an important role in maintaining intestinal homeostasis. The specific objective of this study was to explore the effects of spermidine on intestinal morphology, metabolites, and microbial diversity in mice. We showed that 0.3 mmol/L of spermidine significantly promoted the growth of ileal villi (p < 0.05), and 3.0 mmol/L of spermidine significantly increased the body weight of mice and promoted the growth of jejunum villi (p < 0.05). The 16S rDNA sequencing results indicated that 3.0 mmol/L of spermidine affected the balance of the intestinal flora by increasing the abundance of intestinal Lactic acid bacteria and reducing the abundance of harmful bacteria (Turicibacter and Alistipes). Additionally, spermidine affects the levels of microbial metabolites such as succinic acid and Pantetheine. In summary, spermidine affects intestinal morphology and regulates intestinal flora and metabolites, and this study has provided a new understanding of spermidine’s effects on the intestinal tract.