Abnormal beta and gamma frequency neural oscillations mediate auditory sensory gating deficit in schizophrenia.
Abnormal beta and gamma frequency neural oscillations mediate auditory sensory gating deficit in schizophrenia.
复制标题
异常的β和γ频率神经振荡介导精神分裂症的听觉感觉门控缺陷。
DOI：
10.1016/j.jpsychires.2020.01.014
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发表时间：
2020
影响因子：
4.8
通讯作者：
Brenner,ColleenA
中科院分区：
文献类型：
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作者：
Nguyen,AnnT;Hetrick,WilliamP;O'Donnell,BrianF;Brenner,ColleenA
背景感觉门控是大脑对无关和重复刺激的反应受到抑制的过程。精神分裂症（SZ）的感觉门控缺陷通常是通过对成对点击范式反应的P50事件相关电位（ERP）振幅的比值或差值来测量的。虽然P50门控效应通常与S1和S2 P50 ERPs的峰值幅度相关，但越来越多的证据表明，抑制过程可能反映在β（20-30 Hz）和γ（30-50 Hz）频带的点击间隔期间诱发或诱导的振荡活动。因此，我们研究了频率比活性之间的关系，点击间隔与门控效应的时间和频率domain. Methods配对听觉刺激提出了131名参与者与精神分裂症和196名健康对照（HC）。P50 ERP幅度S1和S2以及平均和单次试验β（20-30 Hz）和γ（30-50 Hz）频率功率在点击间的间隔从CZ电极site.ResultsIn时域，P50门控赤字是明显的比率和差异分数。这种影响主要是由于患者组的S1振幅较小。SZ患者表现出较少的诱发β和γ功率，特别是在0-100 ms的时间点，响应于S1。早期（0-100毫秒）诱发的β和γ反应是至关重要的，在确定的S1振幅和范围的P50门控整个延迟间隔HC和SZ。ConclusionOur研究结果支持中断在最初的感觉登记SZ，并不支持一个积极的机制，在整个延迟间隔。在延迟间期中对S1和早期β和γ频率振荡的反应程度提供了关于支持听觉感觉门控的机制的信息，并且可以提供用于研究支持感觉抑制的机制的框架。
BackgroundSensory gating is a process in which the brain's response to irrelevant and repetitive stimuli is inhibited. The sensory gating deficit in schizophrenia (SZ) is typically measured by the ratio or difference score of the P50 event-related potential (ERP) amplitudes in response to a paired click paradigm. While the P50 gating effect has usually been measured in relation to the peak amplitude of the S1 and S2 P50 ERPs, there is increasing evidence that inhibitory processes may be reflected by evoked or induced oscillatory activity during the inter-click interval in the beta (20–30 Hz) and gamma (30–50 Hz) frequency bands. We therefore examined the relationship between frequency specific activity in the inter-click interval with gating effects in the time and frequency domains.MethodPaired-auditory stimuli were presented to 131 participants with schizophrenia and 196 healthy controls (HC). P50 ERP amplitudes to S1 and S2as well as averaged- and single-trial beta (20–30 Hz) and gamma (30–50 Hz) frequency power during the inter-click interval were measured from the CZ electrode site.ResultsIn the time domain, P50 gating deficits were apparent in both ratio and difference scores. This effect was mainly due to smaller S1 amplitudes in the patient group. SZ patients exhibited less evoked beta and gamma power, particularly at the 0–100 ms time point, in response to S1. Early (0–100 ms) evoked beta and gamma responses were critical in determining the S1 amplitude and extent of P50 gating across the delay interval for both HC and SZ.ConclusionOur findings support a disruption in initial sensory registration in those with SZ, and do not support an active mechanism throughout the delay interval. The degree of response to S1 and early beta and gamma frequency oscillations in the delay interval provides information about the mechanisms supporting auditory sensory gating, and may provide a framework for studying the mechanisms that support sensory inhibition.