Localisation and expression of aquaporin subtypes in epithelial ovarian tumours
Localisation and expression of aquaporin subtypes in epithelial ovarian tumours
复制标题
水通道蛋白亚型在上皮性卵巢肿瘤中的定位和表达
DOI：
10.14670/hh-26.1197
复制
发表时间：
2011-09-01
影响因子：
2
通讯作者：
Yan, Chun-xiao
中科院分区：
文献类型：
--
作者：
Yang, Jian-Hua;Yu, Yu-Qun;Yan, Chun-xiao
为了解AQP亚型在卵巢上皮性肿瘤中的定位和表达，采用免疫组织化学方法检测了AQP1-9在30例良性肿瘤、30例交界性肿瘤、50例恶性肿瘤和20例正常卵巢组织中的定位表达。多种AQP亚型在卵巢上皮性肿瘤中表达，每种AQP亚型表现出不同的定位和表达模式。AQP1主要表达于微血管内皮细胞，AQP2-9主要表达于肿瘤细胞。大多数AQP亚型共定位于良性肿瘤上皮细胞的基侧膜和恶性肿瘤细胞的质膜。AQP1、AQP5、AQP6、AQP7、AQP8、AQP9的阳性率均在50%以上，而AQP2、AQP3、AQP4的阳性率仅为10~40%。AQP1、5和9在恶性肿瘤和交界性肿瘤中的表达显著高于良性肿瘤(P
To characterise AQP subtype localisation and expression in epithelial ovarian tumours, immunohistochemistry was used to assess the localisation and expression of AQP1-9 in 30 benign tumour cases, 30 borderline tumour cases, 50 malignant tumour cases and 20 normal ovarian tissue cases. Multiple AQP subtypes were expressed in epithelial ovarian tumours, with each AQP subtype displaying a different pattern of localisation and expression. AQP1 was mainly expressed in the microvascular endothelium, and AQP 2-9 were mainly expressed in tumour cells. Most AQP subtypes co-localised in the basolateral membranes of the epithelia of benign tumours and plasma membranes of malignant tumour cells. The positive rates for AQP1, 5, 6, 7, 8, and 9 were over 50%, but those for AQP2, 3 and 4 were only 10-40%. The expression of AQP1, 5 and 9 in malignant and borderline tumours was significantly higher than that in benign tumours (P