Viability and MR detectability of iron labeled mesenchymal stem cells used for endoscopic injection into the porcine urethral sphincter
Viability and MR detectability of iron labeled mesenchymal stem cells used for endoscopic injection into the porcine urethral sphincter
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DOI：
10.1002/nbm.3339
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发表时间：
2015-08
影响因子：
2.9
通讯作者：
S. Will;P. Martirosian;F. Eibofner;F. Schick;R. Bantleon;M. Vaegler;G. Grözinger;C. Claussen;U. Kramer;J. Schmehl
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文献类型：
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作者：
S. Will;P. Martirosian;F. Eibofner;F. Schick;R. Bantleon;M. Vaegler;G. Grözinger;C. Claussen;U. Kramer;J. Schmehl
对功能受损组织的直接干细胞治疗需要靶区有足够数量的细胞，并需要一种方法来验证细胞在随后的时间过程中的命运。体内核磁共振铁标记间充质干细胞已被建议符合这些要求。该研究旨在评估间充质干细胞的增殖、迁移、分化和黏附效应，以及获得的铁标记策略的铁负荷。在将标记细胞注射到猪的尿道括约肌后，使用核磁共振对标记细胞进行了长达6个月的监测。
Direct stem cell therapies for functionally impaired tissue require a sufficient number of cells in the target region and a method for verifying the fate of the cells in the subsequent time course. In vivo MRI of iron labeled mesenchymal stem cells has been suggested to comply with these requirements. The study was conducted to evaluate proliferation, migration, differentiation and adhesion effects as well as the obtained iron load of an iron labeling strategy for mesenchymal stem cells. After injection into the porcine urethral sphincter, the labeled cells were monitored for up to six months using MRI.