CRH-BP: the regulation and function of a phylogenetically conserved binding protein.
CRH-BP: the regulation and function of a phylogenetically conserved binding protein.
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DOI：
10.2741/1931
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发表时间：
2006-05
期刊：
影响因子：
--
通讯作者：
N. Westphal;A. Seasholtz
中科院分区：
文献类型：
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作者：
N. Westphal;A. Seasholtz
促肾上腺皮质激素释放激素结合蛋白（CRH- bp）是一种37 kDa分泌的糖蛋白，能高亲和力结合CRH和尿皮质素，并且在结构上与CRH受体无关。CRH-BP同源基因已在多种无脊椎动物和脊椎动物中被发现。它在整个进化过程中是高度保守的，表明维持生物活性所必需的结构构象。CRH- bp是CRH活性的重要调节剂；它可以抑制促肾上腺皮质激素诱导的促肾上腺皮质激素分泌，并可能在促肾上腺皮质激素释放的中心部位发挥类似的作用。虽然CRH-BP的功能被认为主要是抑制性的，但最近的研究表明，在大脑和垂体中可能存在新的功能角色。应激和代谢因素对CRH-BP表达的调节与体内CRH-BP表达改变模型一致。生殖激素对垂体CRH-BP的正向调节表明应激轴与生殖轴之间可能存在其他相互作用。虽然近期的研究主要集中在CRH- bp的进化保护、扩展的表达位点、调控和体内功能，但更全面地了解CRH- bp的中枢和外周功能及其作用机制将有助于阐明其在CRH失调疾病的病因或治疗中的潜在作用。
Corticotropin Releasing Hormone-Binding Protein (CRH-BP), a 37 kDa secreted glycoprotein, binds both CRH and urocortin with high affinity and is structurally unrelated to the CRH receptors. CRH-BP orthologues have been identified in multiple invertebrate and vertebrate species. It is strongly conserved throughout evolution, suggesting the maintenance of a structural conformation necessary for biological activity. CRH-BP is an important modulator of CRH activity; it inhibits CRH-induced ACTH secretion from pituitary corticotropes and may exert similar actions at central sites of CRH release. While the function of CRH-BP is thought to be primarily inhibitory, recent studies indicate that novel functional roles may exist in both the brain and pituitary. Regulation of CRH-BP expression by stress and metabolic factors are consistent with in vivo models of altered CRH-BP expression. Positive regulation of pituitary CRH-BP by reproductive hormones suggests that additional interactions between the stress and reproductive axes may exist. While recent research has focused on the evolutionary conservation, expanded sites of expression, regulation and in vivo function of CRH-BP, a more complete understanding of the central and peripheral functions of CRH-BP and its mechanisms of action will help elucidate its potential role in the etiology or treatment of disorders of CRH dysregulation.