Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone.
Cardiac Stem Cells for Myocardial Regeneration: They Are Not Alone.
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用于心肌再生的心脏干细胞：它们并不孤单。
DOI：
10.3389/fcvm.2017.00047
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发表时间：
2017
影响因子：
3.6
通讯作者：
Tan JJ
中科院分区：
文献类型：
--
作者：
Leong YY;Ng WH;Ellison-Hughes GM;Tan JJ
心力衰竭是世界范围内的头号杀手，约50%的患者在预后5年内死亡。能够修复心脏受损部分的干细胞的发现创造了心脏再生医学领域，该领域探索各种类型的干细胞，无论是自体的还是内源性的，希望找到“圣杯”干细胞候选人来减缓和逆转疾病进展。然而，在搜索这样的小区候选中存在需要克服的许多挑战。理想的细胞必须在恶劣的梗死环境中存活，在施用后保持其表型，并且植入并被激活以启动体内修复和再生。早期的实验室和床边实验主要集中在骨髓来源的细胞;然而，心脏再生需要各种细胞类型和细胞外基质之间的多重协调和相互作用，以形成新的心肌细胞和血管系统。有一个观察到的趋势，当一个以上的细胞共同管理和共同移植到梗死动物模型的再生程度增强，当与单细胞管理。这篇综述重点介绍了干细胞候选者，这些候选者也在人体试验中进行了测试，并总结了探索心脏再生治疗中各种干细胞之间相互作用的发现。
Heart failure is the number one killer worldwide with ~50% of patients dying within 5 years of prognosis. The discovery of stem cells, which are capable of repairing the damaged portion of the heart, has created a field of cardiac regenerative medicine, which explores various types of stem cells, either autologous or endogenous, in the hope of finding the “holy grail” stem cell candidate to slow down and reverse the disease progression. However, there are many challenges that need to be overcome in the search of such a cell candidate. The ideal cells have to survive the harsh infarcted environment, retain their phenotype upon administration, and engraft and be activated to initiate repair and regeneration in vivo. Early bench and bedside experiments mostly focused on bone marrow-derived cells; however, heart regeneration requires multiple coordinations and interactions between various cell types and the extracellular matrix to form new cardiomyocytes and vasculature. There is an observed trend that when more than one cell is coadministered and cotransplanted into infarcted animal models the degree of regeneration is enhanced, when compared to single-cell administration. This review focuses on stem cell candidates, which have also been tested in human trials, and summarizes findings that explore the interactions between various stem cells in heart regenerative therapy.
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影响因子：
3.7
作者：
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作者：
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通讯作者：
Nadal-Ginard, Bernardo