Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae.
Interactive cost of Plasmodium infection and insecticide resistance in the malaria vector Anopheles gambiae.
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疟疾载体动脉藻类动物疟原虫感染和杀虫剂抗性的相互作用。
DOI：
10.1038/srep29755
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发表时间：
2016-07-19
影响因子：
4.6
通讯作者：
Cohuet A
中科院分区：
文献类型：
--
作者：
Alout H;Dabiré RK;Djogbénou LS;Abate L;Corbel V;Chandre F;Cohuet A
杀虫剂耐药性引起了人们对控制媒介传播疾病的担忧。然而，考虑到媒介和寄生虫之间的生态相互作用，它对寄生虫传播的影响可能是多种多样的。因此，我们研究了与杀虫剂抗性和恶性疟原虫感染相关的适应成本，以及它们对冈比亚按蚊生存和繁殖力的交互成本。在没有感染的情况下，我们观察到与杀虫剂抗性相关的繁殖力成本。然而，与对杀虫剂敏感的蚊子相比，带有 kdr 突变的蚊子的存活率更高，而带有 ace-1R 突变的蚊子的存活率则相同。有趣的是，疟原虫感染仅降低杀虫剂抗性菌株的存活率，而不会降低敏感菌株的存活率，并且感染与繁殖力的增加相关，而与所考虑的菌株无关。这项研究提供了证据，证明仅在选择对杀虫剂具有抗性的蚊子中，疟原虫寄生虫感染与生存成本相关。这表明杀虫剂抗性突变的选择可能扰乱了寄生虫和媒介之间的相互作用，导致感染成本增加。考虑到这种天然蚊子-寄生虫组合的适应成本以及其他生态方面对于预测杀虫剂耐药性的流行病学影响非常重要。
Insecticide resistance raises concerns for the control of vector-borne diseases. However, its impact on parasite transmission could be diverse when considering the ecological interactions between vector and parasite. Thus we investigated the fitness cost associated with insecticide resistance and Plasmodium falciparum infection as well as their interactive cost on Anopheles gambiae survival and fecundity. In absence of infection, we observed a cost on fecundity associated with insecticide resistance. However, survival was higher for mosquito bearing the kdr mutation and equal for those with the ace-1R mutation compared to their insecticide susceptible counterparts. Interestingly, Plasmodium infection reduced survival only in the insecticide resistant strains but not in the susceptible one and infection was associated with an increase in fecundity independently of the strain considered. This study provides evidence for a survival cost associated with infection by Plasmodium parasite only in mosquito selected for insecticide resistance. This suggests that the selection of insecticide resistance mutation may have disturbed the interaction between parasites and vectors, resulting in increased cost of infection. Considering the fitness cost as well as other ecological aspects of this natural mosquito-parasite combination is important to predict the epidemiological impact of insecticide resistance.