DIETARY-PROTEIN ANTIGENEMIA IN HUMORAL IMMUNODEFICIENCY - CORRELATION WITH SPLENOMEGALY
DIETARY-PROTEIN ANTIGENEMIA IN HUMORAL IMMUNODEFICIENCY - CORRELATION WITH SPLENOMEGALY
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DOI：
10.1016/0002-9343(84)90771-x
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发表时间：
1984-01-01
影响因子：
5.9
通讯作者：
GOOD, RA
中科院分区：
文献类型：
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作者：
CUNNINGHAMRUNDLES, C;CARR, RI;GOOD, RA
增强胃肠道对饮食物质的吸收是正常新生儿生活的一个重要特征，也存在于选择性IgA缺乏症和特应性过敏等疾病状态中。低丙种球蛋白血症患者对饮食中牛抗原的吸收增加。即使在隔夜禁食后，大多数患者的血清中也存在大量的这些蛋白质。这些蛋白的含量与脾大小和/或外周淋巴组织肥大有关。三名X连锁无丙种球蛋白血症患者在血清中没有检测到这些蛋白的含量，也没有脾肿大或淋巴结病。低丙种球蛋白血症患者可能有一种特殊的胃肠道粘膜病变，允许长期过度吸收饮食抗原，并可能导致淋巴肥大。
Enhanced gastrointestinal absorption of dietary substances is an important feature of normal neonatal life that also exists in particular disease states such as selective IgA deficiency and atopic allergy. Patients with hypogammaglobulinemia have increased absorption of dietary bovine antigens. Most patients have large amounts of these proteins present in the serum even after an overnight fast. The amounts of such proteins were correlated with spleen size and/or peripheral lymphoid hypertrophy. Three patients with X-linked agammaglobulinemia did not have detectable amounts of these proteins in the serum nor did they have splenomegaly or lymphadenopathy. Hypogammaglobulinemic patients probably have a specific gastrointestinal mucosal lesion that permits the chronic excessive absorption of dietary antigens and may result in lymphoid hypertrophy.