Plasma lipid-bound sialic acid alterations in neoplastic diseases.
Plasma lipid-bound sialic acid alterations in neoplastic diseases.
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肿瘤疾病中血浆脂质结合唾液酸的改变。
DOI：
10.1007/bf01955427
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Hardy,RE
中科院分区：
文献类型：
--
作者：
Dwivedi,C;Dixit,M;Hardy,RE
测定了正常志愿者、非恶性疾病患者和各种癌症患者的血浆脂质结合唾液酸（LSA）。50名正常志愿者、16名非恶性疾病患者、54名乳腺癌、17名肺癌、15名结肠癌、7名卵巢癌、5名前列腺癌、4名白血病、4名胃肠道癌、3名甲状腺癌、3名胰腺癌和2名肾上腺癌患者的平均血浆LSA分别为17.7、23.2、58、85、56.7、46.2、56.7、53.3、31.1、33.2和119.5 mg/dl。正常志愿者血浆LSA值均未升高。血浆LSA水平在男性和女性志愿者中无显著差异。两名风湿性关节炎患者的LSA值略高于正常志愿者的平均值± 2 SD。114名不同癌症患者中有两名的血浆LSA水平在正常范围内，显示出98.2%的测定灵敏度。血浆LSA检测相对简单，可作为多种肿瘤性疾病的肿瘤标志物。
Plasma lipid-bound sialic acid (LSA) was assayed in normal volunteers, patients with non-malignant diseases, and a variety of cancer patients. Mean plasma LSA in 50 normal volunteers, 16 patients with non-malignant diseases, 54 breast cancer, 17 lung cancer, 15 colon cancer, 7 ovarian cancer, 5 prostate cancer, 4 leukemia, 4 gastrointestinal, 3 thyroid cancer, 3 pancreas cancer and 2 adrenal cancer patients were 17.7, 23.2, 58, 85, 56.7, 46.2, 56.7, 53.3, 31.1, 33.2 and 119.5 mg/dl, respectively. None of the normal volunteers had elevated plasma LSA values. Plasma LSA level was not significantly different in male and female volunteers. Two patients with rheumatic arthritis had LSA values slightly elevated over the mean + 2 SD for the normal volunteers. Two out of 114 different cancer patients had plasma LSA levels within normal range exhibiting 98.2% sensitivity of the assay. Plasma LSA, which is relatively simple to assay, may be used as a tumor marker in wide variety of neoplastic diseases.