Comparison of clinical features and survival in patients with hepatitis B and C virus-related hepatocellular carcinoma
Comparison of clinical features and survival in patients with hepatitis B and C virus-related hepatocellular carcinoma
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DOI：
10.1093/jjco/27.2.67
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发表时间：
1997-04-01
影响因子：
2.4
通讯作者：
Tsubono, Y
中科院分区：
文献类型：
--
作者：
Tanizaki, H;Ryu, M;Tsubono, Y
我们分析了185例患者的临床特点和生存与乙型肝炎病毒相关肝细胞癌(乙肝病毒组)和1033年与丙型肝炎病毒相关肝细胞癌(丙肝病毒组)多中心研究中,乙肝病毒组的患者(平均年龄52.1岁)大约10岁比丙肝病毒组(平均年龄62.9岁),肝功能,以吲哚菁绿保留15分钟,是乙肝病毒组(17.5%)比在丙肝病毒组(25.4%),HBV组（55%）高于HCV组（44%），两组间t因子有显著差异：53%的乙肝病毒组T3-4丙肝病毒组的比例为41%,此外,一个更高比例的乙肝病毒组对肿瘤分级2 - 3在门静脉血栓(20.3%),低分化肝细胞癌(7%)与丙肝病毒组(分别为7.1%和5%),单变量分析认为贫穷的肝细胞癌的预后因素是乙肝病毒,年龄小于或等于50年,临床阶段ii iii, AFP水平高,更多的肿瘤,在多因素分析中，AFP水平高、肿瘤数量多、门静脉2-3、肝静脉2-3有肿瘤血栓，而HBV、年龄、临床分期、肿瘤大小等因素对预后的影响不明显，提示HBV本身对预后的影响不强于HCV。
We analyzed the clinical characteristics and survival of 185 patients with hepatitis B virus-related hepatocellular carcinoma (HBV group) and 1033 with hepatitis C virus-related hepatocellular carcinoma (HCV group) by multi center study, The patients in the HBV group (mean age 52.1 yr) were about 10 years younger than those in the HCV group (mean age 62.9 yr), Liver function, as measured by indocyanine green retention at 15 min, was better in the HBV group (17.5%) than in the HCV group (25.4%), A higher proportion of the HBV group (55%) than the HCV group (44%) had clinical stage I, T-factor differed significantly between the groups: 53% of the HBV group were T3-4 compared with 41% of the HCV group, Furthermore, a higher proportion of the HBV group were graded 2-3 for tumor thrombus in the portal vein (20.3%) and had poorly differentiated hepatocellular carcinoma (7%) compared with the HCV group (7.1% and 5% respectively), Univariate analysis identified poor prognostic factors for hepatocellular carcinoma as HBV, age less than or equal to 50 yr, clinical stage II-III, a high AFP level, higher number of tumors, larger tumor size, tumor thrombus in the portal vein 2-3 and in the hepatic vein 2-3, On multivariate analysis, poor prognostic factors were a high AFP level, higher number of tumors, tumor thrombus in the portal vein 2-3 and in the hepatic vein 2-3, but not HBV, age, clinical stage or tumor size, These results suggest that HBV itself is not a stronger prognostic factor than HCV.