MMSET is overexpressed in cancers: Link with tumor aggressiveness
MMSET is overexpressed in cancers: Link with tumor aggressiveness
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DOI：
10.1016/j.bbrc.2008.12.093
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发表时间：
2009-02-20
影响因子：
3.1
通讯作者：
Moreaux, Jerome
中科院分区：
文献类型：
--
作者：
Kassambara, Alboukadel;Klein, Bernard;Moreaux, Jerome
MMSET在发育早期普遍表达，它的缺失与称为Wolf-Hirschhorn综合征的畸形综合征有关。它与t(4：14)(p16：q32)染色体易位有关，t(4：14)(p16：q32)染色体易位是多发性骨髓瘤(MM)中第二常见的易位，与最差的预后有关。MMSET的表达已被证明促进多发性骨髓瘤的细胞黏附、克隆生长和致瘤性。最近发现，在多形性胶质母细胞瘤中，MMSET的表达随着肿瘤增殖活性的增加而增加。这些数据表明，MMSET可能与肿瘤的发生和/或进展有关。因此，我们使用公开的基因表达数据，包括肿瘤微阵列数据库，比较了MMSET在40种人类肿瘤类型-脑、上皮、淋巴组织中的表达与其正常组织中的表达。我们发现，与正常对照相比，MMSET在15例癌症中显著过度表达。此外，在上述许多类型的癌症中，MMSET与肿瘤侵袭性或预后有关。综上所述，这些数据表明MMSET可能在许多癌症中起致病作用。确定MMSET的靶点及其在细胞生长和存活中的作用将是了解MMSET如何与肿瘤发展相关的关键。(C)2008 Elsevier Inc.保留所有权利。
MMSET is expressed ubiquitously in early development and its deletion is associated with the malformation syndrome called Wolf-Hirschhorn syndrome. It is involved in the t(4:14) (p16: q32) chromosomal translocation, which is the second most common translocation in multiple myeloma (MM) and is associated with the worst prognosis. MMSET expression has been shown to promote cellular adhesion, clonogenic growth and tumorigenicity in multiple myeloma. MMSET expression has been recently shown to increase with ascending tumor proliferation activity in glioblastoma multiforme. These data demonstrate that MMSET could be implicated in tumor emergence and/or progression. Therefore, we compared the expression of MMSET in 40 human tumor types - brain, epithelial, lymphoid - to that of their normal tissue counterparts using publicly available gene expression data, including the Oncomine Cancer Microarray database. We found significant overexpression of MMSET in 15 cancers compared to their normal counterparts. Furthermore MMSET is associated with tumor aggressiveness or prognosis in many types of these aforementioned cancers.Taken together, these data suggest that MMSET potentially acts as a pathogenic agent in many cancers. The identification of the targets of MMSET and their role in cell growth and survival will be key to understand how MMSET is associated with tumor development. (C) 2008 Elsevier Inc. All rights reserved.