Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
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DOI：
10.1210/edrv.22.2.0428
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发表时间：
2001-04
影响因子：
20.3
通讯作者：
G. Pearson;Fred L Robinson;T. Gibson;Bing-e Xu;M. Karandikar;K. Berman;M. Cobb
中科院分区：
文献类型：
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作者：
G. Pearson;Fred L Robinson;T. Gibson;Bing-e Xu;M. Karandikar;K. Berman;M. Cobb
促分裂原活化蛋白（MAP）激酶包括普遍存在的脯氨酸导向的蛋白丝氨酸/苏氨酸激酶家族，其参与控制细胞内事件的信号转导途径，包括对激素的急性反应和生物体中的主要发育变化。MAP激酶位于蛋白激酶级联中。本文综述了哺乳动物MAP激酶的调节和功能。影响MAP激酶功能的非酶机制和基因破坏研究的结果突出显示。特别强调ERK 1/2。
Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.